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Merck · 10 hours ago

Senior Scientist, In Vivo Cardiometabolic Diseases

USA - California - South San Francisco (Grand Ave)

Full-time

Hybrid

Mid, Senior Level

$131K/yr - $207K/yr

1+ years exp

Merck is a leading company in the pharmaceutical industry, and they are seeking a highly innovative and rigorous Senior Scientist to lead research in cardiometabolic diseases. The successful candidate will manage complex research projects, develop in vivo animal models, and collaborate across teams to advance therapeutic targets for cardiovascular and renal disorders.

BiotechnologyHealth CareMedicalPharmaceutical

Comp. & Benefits

H1B Sponsored

Responsibilities

Independently initiate and lead discovery projects to uncover and validate therapeutic targets for cardio-renal diseases

Establish and characterize renal, cardiovascular, and metabolic animal models, utilizing functional in vivo endpoints, tissue/plasma genomics/proteomics/transcriptomics/metabolomics, and in vitro cell-based and biochemical assays

Develop and optimize in vitro systems and cell-based functional assays for mechanism-of-action studies and compound profiling and screening

Integrate omics data (including single-cell transcriptomics from patient-derived tissues) to inform target selection strategies

Leverage imaging strategies (e.g., confocal fluorescence microscopy or intravital multiphoton microscopy) to investigate quantitative disease endpoints

Spearhead collaborative projects across multidisciplinary teams and co-manage partnerships with external academic and industry collaborators

Present impactful findings at internal and external meetings and contribute to scientific publications and technical reports

Diligently document research activities using electronic lab notebooks; take on shared lab-based responsibilities

Qualification

Vivo Animal ModelsCardiovascular Disease BiologyMulti-Omics ApproachesData AnalysisVitro StudiesSurvival SurgeriesScientific CommunicationTeam CollaborationProblem SolvingMentoring

Required

Bachelor's (with 7 years), Master's (with 4 years) or Ph.D. (with 1 year) in Biology, Physiology or a related discipline and relevant experience in academic or industrial settings

Extensive hands-on experience in developing and characterizing in vivo rodent models for renal (e.g. DKD, ADPKD, FSGS) and cardiovascular disease (e.g. heart failure, ASCVD), including survival surgeries (e.g., osmotic mini-pump implantation), cardiovascular phenotyping (echocardiography, hemodynamic assessments), renal phenotyping (glomerular filtration rate measurements, assess serum and urinary biomarkers), and/or metabolic cage measurements

Experience in designing, executing, and interpreting in vitro and ex vivo experiments

Strong record of impactful publications, oral and poster presentations at international conferences, and recognition for research excellence

Proven ability to be a team player, lead collaborative cross-functional projects, and manage complex non-clinical studies

Advanced skills in scientific communication, data analysis (e.g. RStudio, GraphPad Prism, Ingenuity Pathway Analysis), statistical methods, and electronic lab documentation

Strategic and independent thinker with a drive to innovate and initiate, own and efficiently advance projects through the discovery pipeline. Proven ability to understand disease mechanisms and solve complex problems by undertaking innovative approaches and applying state-of-the art technologies

Preferred

Proficiency in iPSC-based assays and CRISPR/Cas9 gene editing

Demonstrated expertise in multi-omics approaches (single-cell RNA-seq, tissue/plasma proteomics) and data integration for target identification and validation