Oak Ridge Institute for Science and Education · 1 week ago
FDA postdoctoral fellowship - Assessment of mesenchymal stromal cell extracellular vesicle mediation of vascular-immune cell interactions
Silver Spring, MD
Full-time
Onsite
New GradThe Oak Ridge Institute for Science and Education is collaborating with the U.S. Food and Drug Administration (FDA) to offer a postdoctoral fellowship focusing on mesenchymal stromal cell-derived extracellular vesicles for treating systemic lupus erythematosus. The fellow will engage in interdisciplinary research, investigating the modulation of vascular-immune cell interactions and the impact of these extracellular vesicles on disease progression.
Government Administration
No H1B
U.S. Citizen Only
Responsibilities
Investigate how MSC-EVs can modulate key cellular players in SLE-associated cardiovascular complications—specifically pericytes, endothelial cells, and monocytes
Explore how manufacturing conditions influence MSC-EV production and function in the context of SLE
Gaining hands-on experience with advanced cell culture techniques, extracellular vesicle isolation and characterization, and complex 2D/3D co-culture systems
Determine the impact of mesenchymal stromal cell extracellular vesicles (MSC-EVs) on cell-types relevant to systemic lupus erythematosus (SLE)
Characterize MSC-EVs derived from different manufacturing conditions (media, flask vs. bioreactor etc)
Develop SLE co-cultures to investigate the role of pericytes in modulating vascular inflammation
Professional development through publication in high-impact journals and presentation at national conferences as well as preparation for future careers related to product research and development, quality control, regulatory science, and clinical translation
Qualification
Required
The qualified candidate should have received a doctorate in one of the relevant fields (biomedical engineering) or currently pursuing with an expected graduation date before May 31, 2026. Degree must have been received within the past three years
Citizenship: U.S. Citizen Only
Degree: Doctoral Degree received within the last 36 months or anticipated to be received by 5/31/2026 11:59:00 PM
Preferred
The preferred candidate would have demonstrated experience with 5 or more of the following research areas/techniques: cell culture (i.e. cell manufacturing), extracellular vesicle manufacturing and characterization, high content imaging, biomaterials, bioreactors, multiomics (proteomics/metabolomics), immunology, machine learning/AI, single cell profiling
Benefits
Proof of health insurance is required for participation in this program.
Participants do not become employees of FDA, DOE or the program administrator, and there are no employment-related benefits.
Company
Oak Ridge Institute for Science and Education
The Oak Ridge Institute for Science and Education is a U.S.
Founded in 1992
501-1000 employees
Funding
Current Stage
Late StageCompany data provided by crunchbase