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Arrowhead Pharmaceuticals · 10 hours ago

Summer Intern, CMC Small Scale Process Development

Verona, Wisconsin, United States

Internship

Onsite

Intern

$21/hr - $21/hr

Start in 2026 Summer

Arrowhead Pharmaceuticals, Inc. is a clinical stage biopharmaceutical company focused on developing innovative drugs that treat intractable diseases through RNA interference. They are seeking a motivated CMC Small Scale Process Development Intern to support the development of scalable conjugation processes for an RNA therapeutic program, focusing on optimizing the conjugation of a small molecule to RNA.

BiotechnologyHealth CareNanotechnologyPharmaceutical

Comp. & Benefits

No H1B

Responsibilities

Work closely with Process Development scientists to develop and execute reaction and work-up conditions for RNA–small molecule conjugation suitable for manufacturing

Perform synthesis, isolation, purification, and characterization of small molecules and oligonucleotide conjugates

Investigate and optimize conjugation parameters, including reaction conditions, TFF-based work-up, and isolation strategies, to improve yield, purity, and scalability

Perform synthesis of the small-molecule conjugation partner

Analyze small molecules and oligonucleotide conjugates using standard analytical techniques (e.g., NMR, HPLC, mass spectrometry)

Investigate the formation mechanism of a known impurity, as time allows, to inform process controls and impurity mitigation strategies

Maintain clear, accurate, and well-documented laboratory notebooks

Prepare and present project findings to team members at the conclusion of the internship

Qualification

Organic chemistryAnalytical techniquesProcess developmentLaboratory safetyLearning new techniquesOligonucleotide chemistryBioconjugationCommunication skillsProblem-solvingAttention to detail