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Cyclarity Therapeutics · 1 day ago

Senior Research Associate / Associate Scientist (in vivo)

Novato, CA

Full-time

Onsite

Mid, Senior Level

2+ years exp

Cyclarity Therapeutics is a clinical-stage pharmaceutical company focused on developing therapies for atherosclerosis and other diseases of aging. They are seeking a motivated, detail-oriented Senior Research Associate/Associate Scientist to participate in the design and execution of in vivo, in vitro, and ex vivo studies to establish the safety and efficacy of compounds intended for clinical evaluation.

Pharmaceutical

H1B Sponsor Likely

Responsibilities

Independently design and lead in vivo studies to advance drug discovery and development

Perform rodent handling (mouse and rat)

Conduct animal husbandry and routine vivarium upkeep (e.g., cage changes, husbandry, animal monitoring, etc.)

Administer test compounds- IV, IP, SQ, IM injections, and oral gavage

Perform blood collection techniques, including cardiac puncture, submandibular, saphenous vein, and retro-orbital methods

Conduct necropsies, including organ removal, examination, and fixation for histological analysis

Maintain rigorous and accurate laboratory notebooks

Prepare laboratory reagents and solutions

Plan and execute pharmacokinetic studies for new drug candidates

Plan and execute disease models, including study design, dosing, tissue collection, and data analysis

Qualification

Rodent handlingVivo studiesPharmacokinetic studiesHistological analysisFluorescence microscopyAnalytical abilitiesInterpersonal skillsCommunication skillsProblem-solving abilitiesTeamwork

Required

BS or MS degree in biochemistry, cell biology, or a related biomedical field with 2+ years of experience

Extensive hands-on rodent (rat and mouse) handling experience is required

Demonstrated track record (multiple years) of independent in vivo work

Experience with pharmacokinetic studies (drug administration, collection of blood, and collection of urine)

Experience running in vivo efficacy models of disease in rats and mice

Preferred

Histological slide analysis using ImageJ, QuPath, or related software

Fluorescence microscopy and imaging

Experience working with cholesterol and other natural or oxidized sterols

Knowledge in the following areas: cardiovascular, MASH/MAFLD, retinal disease (AMD), Alzheimer's disease, and other diseases of aging

Benefits

Paid vacation and sick leave

Health insurance benefits

Early equity opportunities

Company

Cyclarity Therapeutics

Cyclarity develops interventions targeting toxic forms of cholesterol to provide true disease-modifying treatments for age-related diseases.

Founded in 2019

Novato, California, USA

2-10 employees

https://cyclaritytx.com/

H1B Sponsorship

Cyclarity Therapeutics has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2024 (2)