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Confidential Careers · 5 days ago

Senior Staff Bioinformatics Scientist

California, United States

Full-time

Onsite

Senior Level, Lead/Staff

Confidential Careers is seeking a Senior Staff Bioinformatics Scientist to lead the development and improvement of statistical and algorithmic methods for NGS-based variant detection and minimal residual disease calling. The role involves close collaboration with assay development, bioinformatics engineering, and R&D teams to translate new technologies into robust analytical pipelines.

Human ResourcesRecruiting

Responsibilities

Improve and extend somatic variant-calling algorithms for tumor tissue and cfDNA-based mutation detection

Develop, validate, and refine MRD-calling algorithms with an emphasis on sensitivity, specificity, and robustness

Design and implement benchmarking, evaluation, and quality control (QC) methodologies

Lead troubleshooting efforts, including root-cause analysis of analytical or pipeline failures, and drive corrective actions

Implement algorithms in production-quality code and collaborate with engineering teams to integrate methods into scalable pipelines and workflows

Partner with assay development teams on new technologies and assay iterations requiring customized analysis strategies and algorithm development

Document analytical methods, validation results, and design decisions; clearly communicate findings, limitations, and trade-offs to technical and cross-functional stakeholders

Qualification

Statistical modelingNGS data analysisSoftware implementationPythonRegulated environmentsMachine learningCfDNA analysisCommunication skillsCollaboration skills

Required

Ph.D. in Statistics, Biostatistics, Computer Science, Bioinformatics, Computational Biology, Applied Mathematics, or a related field, with relevant postdoctoral or industry experience

Strong foundation in statistical inference and modeling, including uncertainty quantification and decision thresholding

Prior experience working with genomics data, including WGS or large-scale NGS datasets, and a solid understanding of technical and biological noise sources

Demonstrated software implementation skills in Python and/or a performance-oriented language (e.g., C++, Rust, Java), with experience writing maintainable, testable, production-quality code

Familiarity with standard genomics data formats and tooling (e.g., FASTQ, BAM/CRAM, VCF) and common processing workflows

Experience working in regulated product development environments (e.g., FDA, IVD), including documentation practices, analytical validation, and design controls

Excellent communication and collaboration skills, with the ability to work effectively across research, engineering, and assay development teams

Preferred

Hands-on experience with cfDNA analysis and/or MRD detection, including ultra–low-frequency variant calling and/or epigenetics-based analyses

Machine learning experience, particularly in settings involving class imbalance, model evaluation, calibration, and decision optimization

Experience collaborating closely with assay development teams on experimental design, data analysis planning, and iterative assay optimization

Company

Confidential Careers

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Founded in 2024

Gurgaon, Haryana, IND

2-10 employees

https://confidential.careers

Funding

Current Stage

Early Stage

Leadership Team

Edwin Xiao

Chief Revenue Officer

Company data provided by crunchbase