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AstraZeneca · 18 hours ago

Senior Scientist/Associate Director, Translational PKPD

Waltham, MA

Full-time

Hybrid

Senior Level, Lead/Staff, Director/Executive

$135K/yr - $203K/yr

4+ years exp

AstraZeneca is a company focused on delivering life-changing medicines through scientific innovation. They are seeking a Senior Scientist/Associate Director in Translational PKPD to drive strategy and provide leadership in DMPK science, particularly for Antibody Drug Conjugates and Radioconjugates. The role involves collaborating on projects, exploring PK/PD relationships, and leading strategic scientific initiatives in Oncology.

BiopharmaBiotechnologyHealth CareMedicalPharmaceuticalPrecision Medicine

Comp. & Benefits

H1B Sponsor Likely

Responsibilities

Representing the Translational PKPD group and providing overall scientific leadership for cross functional and external collaborations involving DMPK

Exploring the effects on target and pathway to understand the requirements for efficacy and set a candidate drug target profile (CDTP)

Predicting human dose and regimen together with providing input into exposure and pharmacodynamic (PD) biomarker based decision criteria for early clinical trials

Driving learnings through back translation of early clinical exposure and PD data and providing prioritized future options for clinical testing

Leading and participating in Oncology strategic scientific initiatives and continuous improvement projects by providing expert DMPK knowledge and participating in the development of Discovery or Development strategies in PKPD

Working collaboratively and in continuity with other partner functions

Having a breadth of influence and impact across AstraZeneca Clinical Pharmacology and externally within their discipline

Qualification

DMPK expertiseOncology knowledgePKPD modelingPhD in relevant fieldWinNonLin/Phoenix NLMER programmingSimCYPNonMemBerkeley MadonnaMATLABPublication recordInterpersonal skillsCommunication skillsLeadership skills

Required

PhD in a discipline with a significant component of analysis and quantitation, such as pharmaceutical sciences, quantitative pharmacology, pharmacometrics, engineering, physics, or applied mathematics

Minimum 4 years of relevant industry experience in DMPK/preclinical/translational project-facing role within pharmaceutical R&D

Excellent interpersonal and communication skills coupled with strong influence and leadership skills

Specialist in tools such as WinNonLin/Phoenix NLME, R, SimCYP, NonMem, Berkeley Madonna and MATLAB

Track record of supporting PK, PKPD and TKPD aspects of projects, with a delivery focus and ability to meet timelines to prespecified quality and cost

Track record of demonstrating strong publication record demonstrating comprehensive understanding of DMPK and pharmacology/safety aspects of drug discovery and development

Benefits

Qualified retirement programs

Paid time off (i.e., vacation, holiday, and leaves)

Health, dental, and vision coverage

Company

AstraZeneca

Glassdoor4.1

AstraZeneca is a pharmaceutical company that discovers, develops, manufactures, and markets prescription medicines. It is a sub-organization of Investor.

Founded in 1999

Cambridge, Cambridgeshire, GBR

10001+ employees

https://www.astrazeneca.com

H1B Sponsorship

AstraZeneca has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2021 (2)

2020 (11)