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AstraZeneca · 23 hours ago

Senior Scientist, Immunology Cell Therapy Discovery

Waltham, MA

Full-time

Onsite

Mid, Senior Level

$108K/yr - $163K/yr

0+ years exp

AstraZeneca is a science-led biopharmaceutical company focused on transforming patient outcomes. They are seeking a Senior Scientist to advance novel cell therapies for autoimmune and other immunology indications, leading in vitro functional assays and collaborating with cross-functional teams to drive project planning and delivery.

BiopharmaBiotechnologyHealth CareMedicalPharmaceuticalPrecision Medicine

Comp. & Benefits

H1B Sponsor Likely

Responsibilities

Lead cell therapy target validation and characterize activity of engineered cell therapies using human primary cells and functional co-culture assays; develop and optimize assays; preferred flexibility to additionally contribute to in vivo study design and execution in partnership with in vivo pharmacology

Apply a rigorous, data-driven approach to experimental design, mechanism-of-action studies, and decision-making; use appropriate analytics and visualization; document work to high standards

Drive alignment with other teams including protein engineering, genomics, translational science, clinical, and CMC; translate scientific plans into clear objectives, risks, and decision points for clear communication across groups and to leadership

Collaborate to build and maintain project plans and timelines; manage dependencies and track progress to milestones

Present results and recommendations to teams and leadership; mentor colleagues and foster a productive lab environment

Qualification

Vitro expertiseAutoimmunity experienceData proficiencyCell therapy experienceVivo expertiseAdvanced analyticsCommunicationLeadershipCollaboration

Required

Education: PhD in immunology, cell biology, or related field with 0-5 years experience; or BS or MS with 10+ years of experience in a related field (industry experience strongly preferred)

In vitro expertise: Primary human cell culture and functional cell-based assays; multi‑color flow cytometry; multiplex cytokine detection; assay development

Extensive autoimmunity and/or inflammation experience: Familiarity with in vitro and in vivo model systems for conditions such as rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, inflammatory bowel disease, COPD, fibrosis, etc

Data proficiency: Strong experimental design, analysis, and interpretation; proficiency with tools such as FlowJo and Prism

Communication: Proven ability to communicate complex scientific concepts clearly to technical and non-technical stakeholders

Leadership and collaboration: Strong drive for discovery, scientific curiosity, collaborative mindset; ability to mentor and influence across teams

Preferred

Cell therapy experience: Work with engineered cell products (e.g., T cell subsets, CAR-based modalities); familiarity with novel CAR or antibody target discovery

In vivo expertise: Hands-on planning, oversight, and execution of murine in vivo studies using autoimmune disease models; animal handling; standard dosing and engraftment; analysis of pharmacodynamic, immunophenotyping, and efficacy endpoints

Advanced analytics: Experience integrating complex datasets to guide decisions

Benefits

Short-term incentive bonus opportunity

Eligibility to participate in our equity-based long-term incentive program (salaried roles)

Retirement contribution (hourly roles)

Commission payment eligibility (sales roles)

Qualified retirement program [401(k) plan]

Paid vacation and holidays

Paid leaves

Health benefits including medical, prescription drug, dental, and vision coverage

Company

AstraZeneca

Glassdoor4.1

AstraZeneca is a pharmaceutical company that discovers, develops, manufactures, and markets prescription medicines. It is a sub-organization of Investor.

Founded in 1999

Cambridge, Cambridgeshire, GBR

10001+ employees

https://www.astrazeneca.com

H1B Sponsorship

AstraZeneca has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

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Trends of Total Sponsorships

2021 (2)

2020 (11)