Broad Institute of MIT and Harvard · 1 day ago
Computational Scientist I - Genome-scale Computational Analyses
Cambridge, MA
Full-time
Hybrid
Entry, Mid Level
$88K/yr - $124K/yr
3+ years expThe Broad Institute of MIT and Harvard is seeking a highly motivated Computational Scientist I to work in the Talkowski Laboratory on genome-scale computational analyses related to autism and neuropsychiatric conditions. The candidate will analyze sequencing data, develop analysis workflows, and collaborate with other teams to ensure effective communication and progress on genomic analyses.
BiotechnologyClinical TrialsLife Science
Responsibilities
Member of the team analyzing the sequencing data for the Autism Sequencing Consortium. Through this role, you will assist with the development of analysis aiming at (1) calling and annotating variants in short read sequencing data and (2) developing association frameworks to link detected variants to phenotypes
Responsible for processing incoming blended genome exome (BGE) datasets (i.e., a cost-effective method that combines low-pass whole genome sequencing with deep exome sequencing from a single DNA sample) from various neuropsychiatric cohorts and calling copy-number variants in these samples
Responsible for QCing the results and generating reports to share with collaborators
Interact with other subteams, most notably the methods development team, to develop, improve, standardize, optimize, and distribute new and existing methods for genomics analyses to bridge the progress made by different subteams
Provide collaborative bioinformatics analysis in support of other research projects
Track and communicate progress to internal and external stakeholders at meetings and over Slack
Qualification
Required
Ph.D. in a computational discipline (e.g., computational biology, bioinformatics, biostatistics, computer science, mathematics, physics, statistics) with 3+ years of related experience preferred but exceptional candidates with less experience are welcome to apply
Experience with cloud computing and workflow management systems
Proficient in Python, R, and Unix/Linux, and/or other scripting languages
Proven ability to learn new computational tools and packages
Good foundations in statistics
Ability to work independently and in a team setting in an organized fashion
Good interpersonal and oral/written communication skills in English
Strong ability and experience in interpreting computational results and translating these results into biologically relevant conclusions and hypotheses
Experience in genomics and handling large-scale datasets
Preferred
Experience with Terra, WDL, and Google Cloud is a plus
Knowledge of existing analysis tools, methods, and databases in the field of genomics is a significant plus
Benefits
Medical, dental, vision, life, and disability insurance
401(k) retirement plan
Flexible spending and health savings accounts
At least 13 paid holidays
Winter closure
Paid time off
Parental and family care leave
Employee assistance program
Other Broad benefits
Company
Broad Institute of MIT and Harvard
The Broad Institute brings together a diverse group of individuals from across its partner institutions — undergraduate and graduate students, postdoctoral fellows, professional scientists, administrative professionals, and academic faculty.
1001-5000 employees
H1B Sponsorship
Broad Institute of MIT and Harvard has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
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Trends of Total Sponsorships
2025 (108)
2024 (59)
2023 (73)
2022 (68)
2021 (70)
2020 (93)
Funding
Current Stage
Late StageTotal Funding
$283.25MKey Investors
MacArthur FoundationAlzheimer's Foundation of AmericaMassachusetts Life Sciences Center
2025-11-18Grant· $100M
2020-08-11Grant
2019-09-09Grant· $0.75M
Leadership Team
Dan Shore
Chief Financial Officer
Anne Carpenter
Institute Scientist and Imaging Platform Senior Director
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