Broad Institute of MIT and Harvard · 1 day ago
Computational Scientist for SMaHT Project
Cambridge, MA
Full-time
Onsite
Mid, Senior Level
$88K/yr - $124K/yrThe Broad Institute of MIT and Harvard is involved in the SMaHT Project, which aims to catalog somatic genetic variation across human tissues. They are seeking a Computational Scientist to lead data curation and analyses, overseeing experimental work plans and collaborating with various teams to implement data processing strategies.
BiotechnologyClinical TrialsLife Science
Responsibilities
Design and execute data QC and analysis strategies involving multimodal human tissue datasets, and specifically lead whole-genome short and long-read sequencing data, RNA sequencing, and somatic mutation analyses
Together with others, develop new methodologies and/or evaluate new methods for integrative analysis of genomic data
Apply or develop state-of-the-art computational tools and pipelines to a) assess data quality, b) integrate diverse data types and metadata, and c) detect somatic mutations and subsequent downstream analyses
Collaborate with internal technology development efforts for the application of high-throughput multiomic mapping strategies to diverse biological models
Present ideas and results to the multi-disciplinary members of the SMaHT Network. Prepare written reports and presentations for internal use as well as presentations at conferences
Qualification
Required
PhD in Genomics, Computer Science, Physics, Statistics, Math, Engineering, or a related quantitative discipline is required with 0+ years of experience
Experience with computational analysis, algorithm development, and statistics
Substantial experience analyzing genomic data, preferably whole-genome short and long-read sequencing
Proficiency in at least one modern programming language
Proficient in design and application of analysis pipelines, and able to quickly learn and adapt computational tools for novel analyses
Strong communication skills, with ability to effectively communicate with specialists and non-specialists
Preferred
Experience with a scientific programming environment, such as Python, Julia, R or MATLAB
Experience with cloud computing
Background in genetics or biology
Benefits
Medical
Dental
Vision
Life
Disability insurance
A 401(k) retirement plan
Flexible spending and health savings accounts
At least 13 paid holidays
Winter closure
Paid time off
Parental and family care leave
An employee assistance program
Among other Broad benefits
Company
Broad Institute of MIT and Harvard
The Broad Institute brings together a diverse group of individuals from across its partner institutions — undergraduate and graduate students, postdoctoral fellows, professional scientists, administrative professionals, and academic faculty.
Founded in 2003
1001-5000 employees
H1B Sponsorship
Broad Institute of MIT and Harvard has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (108)
2024 (59)
2023 (73)
2022 (68)
2021 (70)
2020 (93)
Funding
Current Stage
Late StageTotal Funding
$283.25MKey Investors
MacArthur FoundationAlzheimer's Foundation of AmericaMassachusetts Life Sciences Center
2025-11-18Grant· $100M
2020-08-11Grant
2019-09-09Grant· $0.75M
Leadership Team
Dan Shore
Chief Financial Officer
Anne Carpenter
Institute Scientist and Imaging Platform Senior Director
Recent News
2025-12-02
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2025-11-19
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