CHEManager International · 21 hours ago
Scientist - Neuroscience & Immunology
Billerica, MA
Full-time
Onsite
Entry, Mid Level
$84K/yr - $135K/yr
1+ years expEMD Serono is a global leader in Healthcare, Life Science, and Electronics, dedicated to improving lives through innovative solutions. The Scientist will contribute to the discovery of drugs for neurodegenerative and autoimmune diseases, working collaboratively with a team to execute in vitro assays and develop novel therapeutics.
Newspapers
No H1B
Responsibilities
Plan, execute, and lead in vitro studies using human iPSC-derived cell types, or cell lines to support target validation and drug candidate evaluation efforts
Conduct translational biomarker discovery using patient samples or disease-relevant cell-based assays to support pharmacodynamics and target engagement biomarker discovery
Operate a variety of laboratory equipment, including microscopes/automated imagers, flow cytometers, qPCR machines, and spectrophotometers
Record data accurately in the Electronic Laboratory Notebook and maintain records per company policy and legal requirements
Prepare data reports and presentations to lab heads, project teams, and at external meetings
Independently design, execute, analyze, interpret, and troubleshoot experiments to support pipeline progression
Provide technical support to colleagues in own area of expertise when necessary
Work closely with members in RU-N&I to support departmental goals
Qualification
Required
Master's degree in Biology, Neurobiology, Immunology or other Science discipline with 2+ years of laboratory experience in Academia, Pharma, Biotech or CRO
OR PhD in Biology, Neurobiology, Immunology, or other Science discipline with 1+ years of laboratory experience in Academia, Pharma, Biotech or CRO
Preferred
Demonstrated experience with human iPSC-derived neural disease models
Knowledge and hands-on experience in the following areas: Maintaining mammalian cell culture, Primary neurons or glia, Co-culture and triculture systems, PBMCs
Transfection of cells to introduce siRNAs, ASO, or CRISPR-based gene editing tools to suppress or knockout specific genes
Live-cell imaging and imaging analysis experience using an Incucyte or similar automated imager
Immunocytochemistry and/or RNAscope
Gene expression and protein analyses: DNA/RNA isolation, qPCR platforms (Applied biosystems QuantStudio, Nanostring, etc.), western blotting (SallySue, Wes)
Bioanalytical assays: AlphaLISA, Meso Scale Discovery (MSD)
Pharmaceutical industry/ Drug discovery experience
Experience on a pipeline project team
Proficient with research analytical software: GraphPad Prism, Microsoft Office, FIJI (or other image analysis software), QuantStudio
Demonstrated ability to work independently in a self-motivated, pro-active manner
Comfortable with designing and executing experiments based on protocols provided by literature, seminars, and/or other scientists
Good understanding of basic drug discovery principles
Enthusiasm, curiosity, and passion for exploring new biology with relevance to human disease
Desire, demonstration of ownership, accountability, and ability to work efficiently in a fast-paced, high functioning cross-functional team
Excellent interpersonal and written communication skills
Benefits
Health insurance
Paid time off (PTO)
Retirement contributions
Other perquisites
Company
CHEManager International
Wiley’s leading media brand providing first-hand information on the global chemical, life science and process industries
201-500 employees
Funding
Current Stage
Growth StageCompany data provided by crunchbase