Alnylam Pharmaceuticals · 1 week ago
Senior Director, Global Trial Strategy & Operations
United States
Full-time
Hybrid
Director/Executive
12+ years expAlnylam Pharmaceuticals is seeking a Senior Director, Global Trial Strategy & Operations to lead strategic operational execution across the Cardiovascular and TTR portfolio. This role involves partnering with various teams to ensure high-quality execution and operational excellence while influencing delivery through strategic frameworks and cross-functional alignment.
BiotechnologyHealth CareMedicalPharmaceuticalTherapeutics
Hiring Manager
Adam Lentz, MBA
Responsibilities
Partner across Clinical Operations, study teams, and cross-functional partners to drive strategic operational planning, including defining approaches, execution assumptions, timelines, risk management strategies, and delivery frameworks
Develop portfolio-level tracking mechanisms, dashboards, KPIs, and performance analytics to support transparency and data-driven decision-making
Drive prioritization and scenario planning across the Cardiovascular and TTR portfolio, ensuring alignment to critical path and effective deployment of resources
Represent the portfolio in leadership and governance forums, when delegated, ensuring continuity of strategy, alignment, and clarity of decision pathways
Develop, institutionalize, and continuously refine best practices, operating models, playbooks, and standards that reinforce planning rigor, predictable execution, and operational excellence
Partner with study and program leaders to ensure operational plans are documented, actively managed, and responsive to risks, external changes, and portfolio dependencies
Collaborate with cross-functional leaders to support operational readiness, including inspection readiness, vendor oversight frameworks, and compliance
Establish and evolve operating rhythms and governance structures that streamline communication, clarify accountability, and enable timely decisions across programs
Serve as a strategic thought partner to elevate execution focus, challenge assumptions, integrate lessons learned, and support continuous improvement
Partner closely with CROs and external vendors to ensure proactive execution, scope adherence, and high-quality delivery while establishing best practices for oversight
Assist in financial oversight across programs, including forecasting, budget management, investment planning, and long-range portfolio planning
Partner with SM&H, GTO, CPS, and other clinical operations groups to align strategies, improve processes, and drive portfolio delivery
Qualification
Required
Bachelor's degree in Life Sciences or related field required; advanced degree preferred
12+ years of experience in global clinical trial execution within biopharma or CRO environments, with deep operational leadership across full study lifecycle
Demonstrated success operating as a direct report to senior executives and partnering closely at the leadership level to translate strategic priorities into operational execution
Proven track record influencing without direct authority across senior operational and functional leadership
Expertise in clinical operations strategy, program planning, risk management, trial delivery models, and cross-functional execution
Experience developing or implementing operational frameworks, governance models, or delivery standards
Strong presence in senior forums with ability to synthesize complex information and drive alignment through compelling communication
Strong understanding of global regulatory expectations and compliance requirements for clinical trial conduct
Excellent written, verbal, and presentation communication skills
Ability to travel up to 30%
Highly self-directed with ability to drive execution across multiple programs simultaneously
Strong critical thinking, analytical rigor, and ability to navigate ambiguity and drive clarity of action
Skilled influencer able to align diverse stakeholders around shared priorities
Comfortable operating across geographies and time zones in a complex matrix environment
Demonstrated ability to drive impact through strategic frameworks, insights, and alignment rather than formal authority
Operates effectively in a dynamic, fast-paced environment with evolving organizational needs
Company
Alnylam Pharmaceuticals
Alnylam Pharmaceuticals is a biopharmaceutical company focused on the discovery, development and commercialization.
1001-5000 employees
H1B Sponsorship
Alnylam Pharmaceuticals has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2022 (18)
2021 (19)
2020 (7)
Funding
Current Stage
Public CompanyTotal Funding
$4.55BKey Investors
Blackstone Life SciencesBlackstone CreditRegeneron
2025-09-09Post Ipo Debt· $661.25M
2022-09-12Post Ipo Debt· $900M
2022-03-04IPO
Leadership Team
Yvonne Greenstreet
Chief Executive Officer
Jeff Poulton
Chief Financial Officer
Recent News
Clinical Trials Arena
2026-01-16
Longevity.Technology
2026-01-14
2026-01-13
Company data provided by crunchbase