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Vertex · 2 days ago

Vertex Summer Intern 2026, In Vitro, DMPK

Boston, MA

Internship

Hybrid

Intern

$35/hr - $50/hr

Start in 2026 Spring

Vertex is a global biotechnology company that invests in scientific innovation. The Vertex In Vitro, DMPK internship program offers students the opportunity to work on meaningful projects in drug development and gain practical experience in the DMPK functional areas.

Computer Software

No H1B

U.S. Citizen Only

Responsibilities

In vitro PAMPA assay method optimization and validation with literature compounds at various assay conditions to achieve optimal assay performance, in relation to cell-based in vitro screening assays for best in vivo oral bioavailability prediction

Exploration of novel in vitro based assays/techniques that mimic physiological state and in vivo formulation compatible to address questions, and for better prediction of bioavailability

In vitro assay application and expansion to beyond Rule of Five molecules

Data analysis, correlation, and interpretation compared to published sources

Discuss and present research progress with In Vitro team, DMPK department, and stakeholders as appropriate

Qualification

LC-MS instrumentationMolecular biology techniquesData analysisPharmacokinetics knowledgeCommunication skillsCritical thinkingProblem solving

Required

Graduate student in pharmaceutical sciences/pharmacology/analytical chemistry (preferably PhD candidate 2+ years of experience minimum)

Must have experience with operating LC-MS instrumentation

Significant experience with molecular biology (in vitro) techniques and cell-based assays

Proficiency with data importing, analysis/processing and scrutiny, visualization, and interpretation using Analyst, Graphpad Prism, SigmaPlot, or related

History of publications or conference presentation/abstracts

Strong communication skills with ability to summarize and deliver results at high level

Demonstrate outstanding determination, persistence, ambition, critical thinking, and problem solving skills

Full-time on-site in Boston, MA capacity required

Legal authorization to work in the United States, now and in the future. Please note that Vertex does not provide sponsorship for internships or entry level roles within this part of the organization

You must be enrolled in an advanced degree program if graduating before August 2026

You must be available to work full-time, 40 hours per week from May – August 2026