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AstraZeneca · 13 hours ago

Development Scientist III, Viral Vector Analytical Development

US - Boston - MA

Full-time

Onsite

Mid, Senior Level

$138K/yr - $208K/yr

4+ years exp

AstraZeneca's Alexion division is focused on advancing genomic medicine, and they are seeking a Development Scientist III in Viral Vector Analytical Development. This role involves developing and optimizing methods for assessing recombinant Adeno-Associated Virus (rAAV) viral vectors and contributing to regulatory submissions to ensure the success of innovative therapies.

BiopharmaBiotechnologyHealth CareMedicalPharmaceuticalPrecision Medicine

Comp. & Benefits

H1B Sponsor Likely

Responsibilities

Develop, optimize, and implement biochemical and biophysical methods to quantify product and process impurities and perform extended protein characterization of rAAV vectors

Design and execute experiments, review and analyze data, and qualify assays in lab activities

Support tech transfer of biophysical assays to internal teams and external manufacturing/testing organizations for release and characterization testing; serve as subject matter expert for assay troubleshooting and lab investigations

Develop presentations for internal and external audiences, author and review SOPs, technical reports, and assist with analytical sections for regulatory submissions (IND, BLA, etc.)

Serve as analytical lead on cross-functional CMC teams, collaborating with QC, Upstream/Downstream Process Development, Manufacturing, QA, and Regulatory teams to execute genomic medicine analytical strategy

Qualification

Molecular BiologyBiochemistryBiochemical MethodsBiophysical MethodsData Analysis SoftwareAnalytical UltracentrifugationMass SpectrometryProblem-Solving SkillsOrganizational SkillsInterpersonal SkillsTime Management

Required

BS in Molecular Biology, Biochemistry, or related field with 10+ years of relevant experience, a MS with 8+ years of experience, or PhD with 4+ years of experience

Strong hands-on experience in the development, qualification/validation, and transfer of biochemical and biophysical (liquid chromatography, dynamic and multi-angle light scattering, capillary gel electrophoresis, imaged capillary isoelectric focusing) methods for assessing viral vectors and/or rAAV products

Demonstrated ability to utilize standard office software (Excel, PowerPoint, Word, etc.), data analysis software (Chromeleon, Empower, OpenLab, JMP, etc.), and eNotebooks software

Strong analytical mindset and problem-solving skills

Superior organizational and time management skills, ability to prioritize multiple demands and work efficiently with great attention to detail

Excellent interpersonal and collaborative skills, and the ability to work independently and effectively in a highly dynamic environment

The duties of this role are conducted in a mixed office and lab environment. As is typical of a lab-based role, employees must be able, with or without an accommodation to: lift 15 pounds unassisted; work comfortably in a controlled environment with and around biological, infectious, and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours

Preferred

Prior experience with mass spectrometry, surface plasmon resonance, mass photometry, analytical ultracentrifugation or other extended protein characterization techniques is a plus

Candidates should be self-starters, comfortable with autonomy, and embrace opportunities to develop new genomic medicines as part of a dynamic team within Alexion

Benefits

Short-term incentive bonus opportunity

Equity-based long-term incentive program (salaried roles)

Retirement contribution (hourly roles)

Commission payment eligibility (sales roles)

Qualified retirement program [401(k) plan]

Paid vacation and holidays

Paid leaves

Health benefits including medical, prescription drug, dental, and vision coverage

Company

AstraZeneca

Glassdoor4.1

AstraZeneca is a pharmaceutical company that discovers, develops, manufactures, and markets prescription medicines. It is a sub-organization of Investor.

Founded in 1999

Cambridge, Cambridgeshire, GBR

10001+ employees

https://www.astrazeneca.com

H1B Sponsorship

AstraZeneca has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

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Trends of Total Sponsorships

2021 (2)

2020 (11)