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TCG Labs Soleil · 2 days ago

Scientist, Bioanalytical and Translational Sciences (PK, ADA, Biomarkers)

South San Francisco, CA

Full-time

Onsite

Senior Level

$98K/yr - $175K/yr

5+ years exp

TCG Labs-Soleil is seeking a highly motivated and detail-oriented Scientist to join their Bioanalytical/Translational Research team. This role focuses on the design, development, and execution of bioanalytical assays to support clinical and non-clinical programs, including pharmacokinetics, anti-drug antibody, and biomarker assessments.

Biotechnology

Responsibilities

Design, develop, optimize, and qualify ligand binding assays (LBA) for:

Pharmacokinetics (PK)

Immunogenicity (ADA)

Biomarker detection (exploratory and translational)

Perform non-clinical sample analysis to support discovery and development programs

Troubleshoot assay performance issues, implement improvements, and document method changes

Conduct critical reagent labeling (e.g., biotinylation, fluorophore conjugation) and manage reagent inventory

Maintain accurate and detailed records in electronic lab notebooks (ELNs) and ensure compliance with internal quality systems

Analyze and interpret data; present findings to project teams

Coordinate and oversee method development, transfer, and validation activities at external bioanalytical labs

Review protocols, reports, and data from CROs to ensure quality and compliance with regulatory expectations

Serve as a technical point of contact for troubleshooting and assay-related discussions with external partners

Work closely with Research, Nonclinical Development, Translational Sciences, and Clinical Development teams to align bioanalytical strategies with program goals

Qualification

Ligand binding assaysMSD platformsELISA platformsReagent labelingNon-clinical sample analysisTroubleshooting skillsDocumentationOrganizational skillsCross-functional collaboration

Required

Degree in Biochemistry, Molecular Biology, Pharmacology, or related field: BS + 8 years, MS + 5 years, or PhD + 2 years of relevant hands-on industry experience in bioanalytical or immunoassay settings

Strong experience in ligand binding assays for PK, ADA, and biomarker applications

Proficiency with MSD (electrochemiluminescence) and ELISA platforms

Demonstrated ability to troubleshoot and optimize assay performance

Experience with non-clinical sample matrices (e.g., rodent, NHP plasma or serum)

Expertise in reagent labeling and qualification (biotinylation, conjugation)

Excellent documentation and organizational skills