Alnylam Pharmaceuticals · 1 day ago
Sr. Scientist, Clinical Pharmacology
Cambridge, MA
Full-time
Onsite
Mid, Senior Level
$132K/yr - $178K/yr
2+ years expAlnylam Pharmaceuticals is a leader in RNAi therapeutics, seeking a Sr. Scientist in Clinical Pharmacology to support their expanding clinical portfolio. The role involves providing pharmacokinetic and pharmacodynamic support, conducting analyses, and collaborating with various project teams to guide development decisions.
BiotechnologyHealth CareMedicalPharmaceuticalTherapeutics
Responsibilities
Represent Clinical Pharmacology and provide PKPD support and guidance to early and clinical stage project teams
Lead the analysis, interpretation, integration and reporting of clinical pharmacokinetic & pharmacodynamic data
Conduct PK/PD analyses and data visualization to guide development decisions on project teams; ability to use model-based approaches to aid decision making
Provide PKPD input for regulatory submissions such as briefing documents, IND, CTA and NDA
Contribute to protocol preparation, study execution, data review/analysis, study reports and regulatory document preparation
Closely partner with Research, Bioanalytical, Clinical development, Regulatory, Project Management, biostatistics and other R&D functions
Maintain a current understanding of the literature and knowledge in the clinical pharmacology, modeling and simulation field
Qualification
Required
Ph.D. in Pharmacokinetics, Pharmacology, Pharmaceutics or other relevant field with 2-3 years' experience in pharmaceutical industry, or M.D or Pharm.D. with equivalent experience
Strong knowledge of clinical pharmacology principles in drug development including PKPD, modeling and simulation, ADME concepts, and clinical pharmacology
Hand-on experience in using R and other data visualization techniques for representation of PKPD data
Proficient in using Phoenix WinNonlin, Phoenix NLME, R, NONMEM, or other pharmacokinetic, modeling software
Strong communication skills (verbal and written) and presentation skills are required
Excellent interpersonal and collaboration skills and the ability to function in a highly matrixed team environment are essential
Preferred
Training in application of pharmacometric principles or software would be a plus
Benefits
Comprehensive benefits including medical, dental, and vision coverage
Life and disability insurance
A lifestyle reimbursement program
Flexible spending and health savings accounts
A 401(k) with a generous company match
Paid time off
Wellness days
Holidays
Two company-wide recharge breaks
Generous family resources and leave
Company
Alnylam Pharmaceuticals
Alnylam Pharmaceuticals is a biopharmaceutical company focused on the discovery, development and commercialization.
1001-5000 employees
H1B Sponsorship
Alnylam Pharmaceuticals has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2022 (18)
2021 (19)
2020 (7)
Funding
Current Stage
Public CompanyTotal Funding
$4.55BKey Investors
Blackstone Life SciencesBlackstone CreditRegeneron
2025-09-09Post Ipo Debt· $661.25M
2022-09-12Post Ipo Debt· $900M
2022-03-04IPO
Leadership Team
Yvonne Greenstreet
Chief Executive Officer
Jeff Poulton
Chief Financial Officer
Recent News
2026-01-13
2026-01-13
Company data provided by crunchbase