Alexion Pharmaceuticals, Inc. · 17 hours ago
Development Scientist III, Viral Vector Analytical Development
Boston, Massachusetts, United States of America
Full-time
Hybrid
Mid, Senior Level
$138K/yr - $208K/yr
4+ years expAlexion Pharmaceuticals, Inc. is focused on advancing genomic medicine and is seeking a Development Scientist III in Viral Vector Analytical Development. The role involves developing and optimizing methods for assessing recombinant Adeno-Associated Virus (rAAV) viral vectors, collaborating with various teams to drive innovation and contribute to regulatory submissions.
BiotechnologyHealth CareMedicalTherapeutics
Responsibilities
Develop, optimize, and implement biochemical and biophysical methods to quantify product and process impurities and perform extended protein characterization of rAAV vectors
Design and execute experiments, review and analyze data, and qualify assays in lab activities
Support tech transfer of biophysical assays to internal teams and external manufacturing/testing organizations for release and characterization testing; serve as subject matter expert for assay troubleshooting and lab investigations
Develop presentations for internal and external audiences, author and review SOPs, technical reports, and assist with analytical sections for regulatory submissions (IND, BLA, etc.)
Serve as analytical lead on cross-functional CMC teams, collaborating with QC, Upstream/Downstream Process Development, Manufacturing, QA, and Regulatory teams to execute genomic medicine analytical strategy
Qualification
Required
BS in Molecular Biology, Biochemistry, or related field with 10+ years of relevant experience, a MS with 8+ years of experience, or PhD with 4+ years of experience
Strong hands-on experience in the development, qualification/validation, and transfer of biochemical and biophysical (liquid chromatography, dynamic and multi-angle light scattering, capillary gel electrophoresis, imaged capillary isoelectric focusing) methods for assessing viral vectors and/or rAAV products
Prior experience with mass spectrometry, surface plasmon resonance, mass photometry, analytical ultracentrifugation or other extended protein characterization techniques is a plus
Demonstrated ability to utilize standard office software (Excel, PowerPoint, Word, etc.), data analysis software (Chromeleon, Empower, OpenLab, JMP, etc.), and eNotebooks software
Strong analytical mindset and problem-solving skills
Superior organizational and time management skills, ability to prioritize multiple demands and work efficiently with great attention to detail
Excellent interpersonal and collaborative skills, and the ability to work independently and effectively in a highly dynamic environment
The duties of this role are conducted in a mixed office and lab environment. As is typical of a lab-based role, employees must be able, with or without an accommodation to: lift 15 pounds unassisted; work comfortably in a controlled environment with and around biological, infectious, and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours
Preferred
Candidates should be self-starters, comfortable with autonomy, and embrace opportunities to develop new genomic medicines as part of a dynamic team within Alexion
Benefits
Short-term incentive bonus opportunity
Equity-based long-term incentive program (salaried roles)
Retirement contribution (hourly roles)
Commission payment eligibility (sales roles)
Qualified retirement program [401(k) plan]
Paid vacation and holidays
Paid leaves
Health benefits including medical, prescription drug, dental, and vision coverage
Company
Alexion Pharmaceuticals, Inc.
Alexion, AstraZeneca Rare Disease is focused on pioneering new possibilities for the rare disease community.
1001-5000 employees
H1B Sponsorship
Alexion Pharmaceuticals, Inc. has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (49)
2024 (57)
2023 (51)
2022 (29)
2021 (27)
2020 (17)
Funding
Current Stage
Public CompanyTotal Funding
$5.8M2020-12-12Acquired
1999-02-12Post Ipo Equity· $5.8M
1996-02-29IPO
Leadership Team
Frederic Chereau
SVP, Strategy and Business Development
Imran Shakur
Director, IRT and Technology Lead
Recent News
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2025-12-20
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