Orna Therapeutics · 23 hours ago
Principal Scientist - PERM
Watertown, MA
Full-time
Onsite
Senior Level, Lead/Staff
$152K/yr - $182K/yr
5+ years expOrna Therapeutics, Inc. is seeking a Principal Scientist to lead bioanalytical assessment and characterization of immunogenicity for novel RNA Lipid Nanoparticle therapeutics. The role involves managing nonclinical development projects, overseeing pharmacodynamic assays, and mentoring junior scientists in bioanalytical methods.
BiotechnologyMedicalPharmaceuticalTherapeutics
Responsibilities
Lead the function of bioanalytical assessment and the characterization of humoral and cellular immunogenicity of novel RNA Lipid Nanoparticle (LNP) therapeutics for the treatment of cancer, autoimmune, and other severe diseases such as multiple myeloma, B-cell lymphoma, and systemic lupus erythematosus
Function as a Key Opinion Leader (KOL) in immunogenicity assessment of LNP therapeutics leader in biotech industry
Lead and manage RNA LNP drug nonclinical development projects, including planning scope, timelines, budget and execution
Direct the execution of Pharmacodynamic (PD) assays and immunogenicity assays
Design and oversee the execution of phase-appropriate preclinical and clinical bioanalytical strategies, including quantitation and characterization of biomarkers using ligand binding assay and immunogenicity evaluations (cytokine, anti-CAR antibody and anti-PEG antibody) of mRNA-LNP therapeutics
Provide data for correlation of drug efficacy, toxicity, prediction of human dose with maximal benefit-to-risk ration, and tests such as pharmacokinetic (PK), anti-drug antibody (ADA), cytokine, and biomarker assays
Ensure timely generation of critical chemical and biological reagents for various bioanalytical assays and qualify the reagents through chemical and physical properties including their size, stability, purity, sequence and bio-reactivity
Direct, supervise, and mentor junior scientists in test procedures such as sample extraction and measurement by bDNA, ELISA, MSD, Luminex and flow cytometry and data interpretation
Qualification
Required
Master's degree in Pharmaceutical Sciences or a related field
5 years of industry experience in nucleic acid therapeutic research and development
2 years of experience in RNA therapeutic development
5 years of experience developing bioanalytical methods to measure drugs and biomarkers
2 years of experience in design and execution of drug immunogenicity evaluation strategies including cytokine and anti-drug antibodies
2 years of experience in CRO management for sample analysis
1 year of experience in generation and qualification of critical reagents
Company
Orna Therapeutics
Orna Therapeutics is a biotechnology company that specializes in fully engineered circular RNA therapeutics to treat various diseases.
51-200 employees
H1B Sponsorship
Orna Therapeutics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (10)
2024 (1)
2023 (5)
2022 (2)
2021 (1)
Funding
Current Stage
Growth StageTotal Funding
$321MKey Investors
MerckMPM Capital
2022-08-16Series B· $221M
2021-02-24Series A· $80M
2020-01-01Seed· $20M
Leadership Team
Frank Neumann
Chief Medical Officer
Recent News
Labiotech UG
2025-11-15
Company data provided by crunchbase