Vertex · 2 days ago
Global Cell and Gene Forecasting Associate Director
Boston, MA
Full-time
Hybrid
Senior Level, Lead/Staff, Director/Executive
$162K/yr - $243K/yr
7+ years expVertex Pharmaceuticals Inc is a global biotechnology company that invests in scientific innovation. As the Associate Director of Cell & Gene Therapy Forecasting, you will lead global forecasting activities for Vertex’s cell and gene therapy portfolio, collaborating with various departments to deliver analytical support that informs business decisions.
Computer Software
Responsibilities
Lead development, refinement, and maintenance of long-range global revenue and demand forecasts for the Heme and Type 1 Diabetes commercial franchises
Build forecasting frameworks suited for disruptive, potentially curative therapies, integrating epidemiology, patient journey/treatment dynamics, operational constraints, and market evolution
Serve as a trusted advisor to senior leaders within Global Commercial Strategy, providing objective, data-driven insights to support decision-making across brand, portfolio, and corporate levels
Drive long-range forecasting activities (LRP), annual planning, and scenario modeling to support business cases, supply planning, manufacturing strategy, and strategic prioritization
Partner closely with Marketing Science, HEOR, Market Access, Medical Affairs, Commercial Development, and Finance to synthesize and integrate insights into forecast models, while ensuring alignment with near-term regional forecasts
Collaborate with marketing science colleagues and external vendors to ensure primary market research is appropriately incorporated into forecasting assumptions and scenario analyses
Work with competitive intelligence teams to evaluate pipeline evolution, competitive launches, and environmental shifts affecting adoption curves and long-term penetration
Coordinate with supply chain and manufacturing partners to align forecasts with capacity planning and operational constraints unique to cell and gene therapy modalities
Develop and maintain advanced forecasting models that appropriately reflect uncertainties, sensitivities, and key market drivers
Produce high-quality deliverables including forecast dashboards, scenario summaries, business cases, and communication materials for leadership discussions
Ensure methodological transparency, strong version control, and best practices in documentation and model governance
Proactively identify emerging trends, risks, and opportunities, and translate them into strategic implications for commercial and enterprise-level planning
Support portfolio-wide analytics, helping harmonize forecasting approaches across cell and gene therapy programs
Provide input into long-term strategic planning activities, opportunity assessments, and resource prioritization across the non-CF pipeline
Represent forecasting in cross-functional working groups and governance forums, ensuring alignment across global, regional, and local teams
Qualification
Required
Deep expertise with in-line forecasting in the pharmaceutical or biotechnology industry; experience with specialty, rare disease, or cell & gene therapy markets strongly preferred
Strong command of forecast modeling approaches across all stages (early clinical, launch, in-line)
Ability to translate complex scientific, clinical, and quantitative information into clear, strategic insights
Excellent communication skills, with the ability to influence senior stakeholders and articulate assumptions, risks, and recommendations
Proficiency with analytical tools (Excel, forecasting platforms, Power BI or similar visualization tools); experience with simulation, sensitivity analysis, or advanced modeling a plus
Demonstrated experience operating in highly cross-functional environments and managing diverse stakeholder needs
Comfort with ambiguity and a problem-solving mindset well-suited to first-in-class or curative therapies where traditional analogs may not exist
Strong project management skills with the ability to handle multiple priorities with speed and precision
Bachelor's degree in a quantitative, scientific, business, or healthcare-related field required; MBA, MS, MPH, or other advanced degree preferred
7–10+ years of pharmaceutical/biotech forecasting or commercial analytics experience, with at least 3+ years in in-line forecasting roles
Demonstrated track record of delivering high-quality forecasts that inform commercial, financial, or strategic decision-making
Preferred
Experience supporting global or multi-region commercial organizations preferred
Prior experience in cell and gene therapy, rare disease, or advanced modalities is advantageous but not required
Benefits
Inclusive market-leading benefits
Medical, dental and vision benefits
Generous paid time off (including a week-long company shutdown in the Summer and the Winter)
Educational assistance programs including student loan repayment
A generous commuting subsidy
Matching charitable donations
401(k)
Company
Vertex
Vendor intelligence that combs through your supplier, manufacturer, logistics data to detect where you're leaving money on the table.
2-10 employees
H1B Sponsorship
Vertex has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
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Trends of Total Sponsorships
2025 (27)
2024 (18)
2023 (7)
2022 (13)
2021 (5)
2020 (7)
Funding
Current Stage
Early StageCompany data provided by crunchbase