Flagship Pioneering · 17 hours ago
Pioneering Medicines: Principal Scientist Bioinformatics
Cambridge, MA USA
Full-time
Onsite
Senior Level, Lead/Staff
$148K/yr - $204K/yr
4+ years expFlagship Pioneering is a biopharmaceutical company focused on developing life-changing treatments. The Principal Scientist Bioinformatics will lead computational efforts on drug discovery programs, analyze omics data, and collaborate with various teams to impact target discovery and patient stratification efforts.
FinanceFinancial ServicesVenture Capital
Responsibilities
Lead Translational Bioinformatics projects in various areas, including but not limited to oncology/I&I, cardiovascular, renal, metabolic and pulmonary diseases
Coach other team members on strategic thinking and next level synthesis and communication skills
Propose, evaluate and champion state-of-the-art computational omics approaches to answer key biological questions
Mine genomics datasets to identify novel targets for small molecule and biological therapies
Apply machine learning and AI approaches to uncover novel insights, including dimensionality reduction, clustering, classification, predictive modeling, and network-based inference
Drive analyses or internalize expertise if needed, for a rich suite of data modalities: bulk and single cell RNAseq/genomics, spatial genomics, proteomics, and state-of-the-art modeling techniques, tailored to specific programs and disease areas
Work closely with the in-vivo, in-vitro and translational research teams to translate biological questions into analytical solutions, including influencing experimental design, analyzing data and visualizing results
Qualification
Required
Ph.D in Bioinformatics, Computational Biology, Biological Sciences, or related discipline and 4+ years of industry experience as a bioinformatics representative on drug discovery programs
Understanding of biology and/or translational research and ability to address biological questions using computational approaches; in-depth knowledge of cancer genomics, tumor immunology, immunology or other related areas
Successful track record collaborating with cross-functional scientific teams
Experience with state-of-the-art methods for next generation sequencing data
Experience integrating genetic, genomic and pathway/network datasets with novel experimental data to derive biological understanding
Fluency in R, Python or any other broadly used programming languages and environments like Code Ocean, AWS, git
Demonstrated application of AI/ML to biological datasets, including algorithm development or use of libraries like scikit-learn, XGBoost, Pinnacle
Excellent problem-solving, teamwork and communication skills, with an ability to effectively interact with people in a dynamic matrix environment, both internally and externally
Preferred
Exposure to translational science, patient stratification, or biomarker discovery in preclinical or clinical contexts
Experience integrating heterogeneous omics data
Knowledge of experimental design and data QC best practices
Prior experience in biotech or pharma
Benefits
Healthcare coverage
Annual incentive program
Retirement benefits
Broad range of other benefits
Company
Flagship Pioneering
Flagship Pioneering is a venture capital firm that invests in life sciences and healthcare companies.
501-1000 employees
H1B Sponsorship
Flagship Pioneering has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (8)
2024 (4)
2023 (4)
2022 (4)
2021 (1)
Funding
Current Stage
Late StageLeadership Team
Noubar Afeyan
Founder and CEO
Chuck Carelli
Chief Financial Officer
Recent News
2026-01-09
koreatechdesk.com
2025-12-27
Company data provided by crunchbase