AbbVie · 15 hours ago
Principal Research Scientist I, Discovery Biotherapeutics
San Francisco, CA
Full-time
Onsite
Senior Level, Lead/Staff
$121K/yr - $230K/yr
6+ years expAbbVie is a company dedicated to discovering and delivering innovative medicines and solutions for serious health issues. They are seeking a Principal Scientist to lead therapeutic programs in biotherapeutics, focusing on biophysical screening and collaboration with oncology teams.
BiotechnologyFinancial ServicesHealth CareMedicalPharmaceuticalVenture Capital
Responsibilities
Lead from the lab to advance large molecule biologics projects from exploratory to optimization stages and drive Go / No Go decisions
Effectively partner with functional and therapeutic areas to achieve project objectives
Identify and integrate cutting-edge technologies and methodologies into screening and assay development, anticipating future trends in drug discovery
Multitask and work within timelines while maintaining a high level of productivity
Supervise 1-2 scientists, evaluate team performance, and is accountable for the effective performance of team
Qualification
Required
BS, MS, or PhD with typically 14+ (BS), 12+ (MS), or 6+ (PhD) years of relevant experience
Experience with biologics, monoclonal antibodies and/or protein therapeutics
Experience advancing Discovery programs from exploratory to candidate nomination
Independently develop and execute biosensor and cell-based platforms to evaluate panels of antibody biotherapeutics
Implement high-throughput epitope binning for large panels of monoclonal antibodies and develop deep knowledge of antibody sequence/function relationships
Evaluate and integrate biomolecular interaction technologies (e.g., SPR) to guide therapeutic candidate selection recommendations
Expert in biophysical characterization instrumentation and methodologies such as SEC, MS, HDX-MS, X-ray crystallography, DSF, DLS, etc
Challenge the status quo and onboard cutting-edge technologies to drive discovery and innovation
Excellent attention to detail, record keeping, and organization
Excellent communication, presentation, and collaboration skills
Preferred
Antibody sequence and structure knowledge
Structure-based molecular modeling and applications with AI/ML and integrating complex datasets to drive data-based decisions
CRO and external partner management
Benefits
Paid time off (vacation, holidays, sick)
Medical/dental/vision insurance
401(k)
Short-term incentive programs
Long-term incentive programs
Company
AbbVie
AbbVie is a biopharmaceutical company focused on immunology, oncology, neuroscience, virology, and aesthetics. It is a sub-organization of AbbVie.
10001+ employees
H1B Sponsorship
AbbVie has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (273)
2024 (190)
2023 (225)
2022 (284)
2021 (186)
2020 (186)
Funding
Current Stage
Public CompanyTotal Funding
$15B2024-02-27Post Ipo Debt· $15B
2023-03-08Post Ipo Equity· $0.25M
2012-12-20IPO
Leadership Team
Robert Michael
Chairman of the Board and Chief Executive Officer
Micah Bregman
Vice President, Global Strategy and Pipeline, Allergan Aesthetics
Recent News
Pharmaceutical Technology
2026-01-13
Company data provided by crunchbase