City Therapeutics · 21 hours ago
Senior Scientist - Statistical Genetics
Cambridge, MA
Full-time
Onsite
Mid, Senior Level
$136K/yr - $154K/yr
3+ years expCity Therapeutics is seeking an enthusiastic, highly motivated statistical geneticist to join their dynamic Data Science team. The role involves leading and supporting next-generation RNAi target discovery efforts, requiring strong statistical genetics expertise to advance target identification and validation strategies.
BiopharmaLife ScienceTherapeutics
Responsibilities
Perform biobank-scale common and rare variant genetic association analyses using scalable cloud-native tools (e.g. Hail, REGENIE)
Develop and implement pipelines for cross-biobank phenotypic curation and harmonization and conduct cross-biobank meta-analyses to identify and validate therapeutic targets
Carry out post-GWAS analyses and interpretation (e.g. fine mapping, colocalization, Mendelian randomization, locus-to-gene scoring)
Develop strategies to identify genetically validated targets by leveraging multi-biobank individual-level data, publicly available summary statistics, and multi-omics integration
Collaborate with disease area biologists in target validation efforts to support existing programs and champion new genetically validated targets across multiple therapeutic areas
Qualification
Required
Ph.D. in statistical genetics, human genetics, or related field with 3-5+ years of relevant post-graduate experience
Deep expertise in statistical genetics with hands-on experience implementing state-of-the-art methods and analysis tools
Experience conducting analyses on cloud research platforms (e.g. DNANexus, All of Us Researcher Workbench) and cloud-computing infrastructures (e.g. AWS)
Proficiency in Python, R, and Linux command-line environments
Experience with programmatic access to external data sources via APIs
Excellent communication skills, demonstrated through high-impact publications and the ability to present complex scientific findings to diverse audiences
Benefits
Medical
Dental
Vision
Life insurance
Health and dependent care FSA accounts
HSA/HRA accounts with company contributions
401(k) with competitive company match
Company
City Therapeutics
City Therapeutics is a biopharmaceutical company focused on developing next-generation small interfering RNAs.
11-50 employees
H1B Sponsorship
City Therapeutics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (4)
2024 (2)
Funding
Current Stage
Early StageTotal Funding
$135MKey Investors
ARCH Venture Partners
2024-10-08Series A· $135M
Leadership Team
Sebastian Trousil
Co-Founder and Chief Operating Officer
Recent News
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