GSK · 16 hours ago
Sr. Principal Scientist, Neurodegeneration
Collegeville, PA
Full-time
Onsite
Senior Level, Lead/Staff
5+ years expGSK is a global biopharma company aiming to positively impact the health of 2.5 billion people by the end of the decade. They are seeking a highly motivated and talented scientific laboratory leader with a strong background in neuroscience to lead research in neurodegenerative diseases and support early-stage drug discovery projects.
BiotechnologyHealth CarePharmaceutical
Responsibilities
Lead biology studies both from/off-bench to support discovery projects by developing target – disease biology hypothesis, establishing and performing in vitro iPSC derived CNS cells/ ex vivo cellular assays primarily using biochemistry expertise combined with molecular and cell biology
Develop novel assays with high translational value to interrogate target or disease biology
Develop testable target and biomarker hypothesis based on Omics data
Optimize and perform in vitro assays to support lead optimization of molecules
Work collaboratively with matrix partners to lead workstreams towards project milestone
Periodically update work status to project teams, matrix partners, and senior stakeholders
Manage time efficiently and be productive when there are competing priorities
Be compliant with GSK policies and SOPs including recording electronic laboratory notebooks, maintaining safety while working in the lab
Qualification
Required
PhD in Biochemistry, preferably in Alzheimer's disease with 5+ years drug discovery experience in industry
Three or more years of experience in leading biology studies in early-stage drug discovery projects
Three or more years of experience in protein isolation from iPS derived cells, human brain/biofluid samples, and characterization using biochemical and mass spectrometric methods
8+ years' experience working with iPSC derived CNS cells and standard laboratory techniques such as cell biology, molecular biology and biochemistry
5+ years' experience in developing assays to investigate target mechanisms/ biology preferably in Alzheimer's disease using iPSC derived cells in 2D- configuration
3+ years' experience in using AI/ML tools to develop biological/mechanistic hypothesis using omic datasets
Preferred
Proficiency in conceptualizing, designing and developing complex assays utilizing different cellular models including primary and hiPSC-derived cells (neuron/microglia/astrocytes)
5+ years deep multidisciplinary expertise in biological mass spectrometry, quantitative proteomics including isotope labeling (SILAC) and label-free techniques and targeted proteomics workflow
5+ year's experience in deploying cell-based target engagement assays and establishing proximal functional pharmacology
Demonstrated ability to work effortlessly in a collaborative and multidisciplinary team environment
Effective communication skills and being proactive at work
Company
GSK
We are uniting science, technology and talent to get ahead of disease together. Our community guidelines: https://gsk.to/socialmedia
10001+ employees
H1B Sponsorship
GSK has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (45)
2024 (56)
2023 (54)
2022 (53)
2021 (54)
2020 (72)
Funding
Current Stage
Public CompanyTotal Funding
$25.51MKey Investors
CARB-X
2021-03-02Grant· $18M
2020-09-23Grant· $7.51M
1978-01-13IPO
Leadership Team
Julie Brown
CFO
Mike Elmore
SVP & Chief Information Security Officer, GSK
Recent News
2026-01-13
South China Morning Post
2026-01-08
2026-01-07
Company data provided by crunchbase