Oxford BioTherapeutics · 22 hours ago
Senior/Principal Scientist IHC
San Jose, California, United States
Full-time
Onsite
Senior Level
$145K/yr - $185K/yr
4+ years expOxford BioTherapeutics is a clinical-stage biotechnology company focusing on the development of antibody therapeutics for cancer treatment. They are seeking a motivated Senior or Principal Scientist to join the Histopathology Lab, where the role involves designing and executing histopathology workflows to evaluate oncology targets and presenting findings to teams and partners.
BiotechnologyGeneticsHealth CareHealth DiagnosticsTherapeutics
Responsibilities
Design and optimize chromogenic IHC assays using FFPE/FF samples; confirm specificity using orthogonal methods (e.g., ISH)
Lead histopathology support for cancer target programs, including materials management, hands-on lab work, mentorship of junior staff, and timeline delivery
Present results, gather feedback, and implement next steps
Use literature and public datasets to guide assay development and target validation
Process tissues and cell pellets into FFPE/frozen blocks; section and stain samples using Leica Bond autostainers
Digitize slides, analyze results, and document data in ELN and presentations
Perform routine lab tasks: sample archiving, equipment maintenance, consumables ordering, logistics
Support tissue database and digital data organization
Qualification
Required
PhD +4 years, or Master's +6 years, or Bachelor's +8 years or more of hands-on experience working in histology and IHC related labs, preferably supporting cancer research in an industry setting
Extensive (>3 years) hands-on experience developing, utilizing, and interpreting immunohistochemistry assays against novel protein targets, using both single and multiplex IHC techniques primarily on FFPE sample slides
Extensive (>3 years) hands-on experience in laboratory histology, including preparation of tissue samples into FFPE and FF blocks, preparation of cell pellet control blocks, cryostat and microtome sectioning, troubleshooting chromogenic IHC and ISH experiments, and independently identifying appropriate next steps in the development of robust, sensitive and specific tissue biomarker assays
Experience with Leica Bond autostainers and reagents relevant to optimizing new IHC assays, typically chromogenic assays
Experience with microscope slide scanners for brightfield and fluorescent imaging, and general experience utilizing whole-slide image analysis software such as HALO
Collaborate effectively in a matrix-managed organization to drive advancement of early-stage projects into translational and clinical development
Be relied upon as a technical expert in the IHC field; provide guidance to colleagues and collaborators, and mentorship to more junior lab colleagues
Preferred
Knowledge in cancer biology, immuno-oncology, and tumor histopathology are each a plus
Strong track record of developing and implementing strategic initiatives to improve scientific and/or operational activities
Relevant experience working with service providers and CROs in the histology space
Excellent organization skills, and evidence of previous success in a growing and fast-paced work environment
Experience regularly presenting IHC assay results in group settings
Top candidates will be collaborative and team oriented, creative problem solvers, resilient to change, and interested in learning opportunities
Experience with cell culture and related molecular biology assays (WB/ELISA/etc.) are additionally a plus
Benefits
Medical, dental and vision insurance for employee and dependents
FSA (Flexible Spending Account)
STD, LTD, Basic Life and AD&D Insurance, Supplemental Life
401(k) Plan
5 sick days per year
11 holidays
Employee Referral Bonus Program
Annual bonus program
New hire stock options
Company
Oxford BioTherapeutics
Oxford BioTherapeutics develops medicines for cancer and companion diagnostics for selected antibody programs.
11-50 employees
H1B Sponsorship
Oxford BioTherapeutics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (2)
2020 (1)
Funding
Current Stage
Early StageTotal Funding
$33.22MKey Investors
Calculus CapitalOxford Finance LLCSilicon Valley Bank
2021-01-01Series Unknown
2018-08-03Series Unknown· $2.6M
2017-01-26Debt Financing· $10M
Leadership Team
Abderrahim Fandi, MD PhD
Chief Medical Officer
Joyce B.
Human Resources and Office Business Partner
Recent News
2025-12-15
MarketScreener
2025-12-10
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