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Compass Pathways · 1 day ago

Principal Scientist, Clinical Sciences

New York, United States

Full-time

Hybrid

Lead/Staff

$160K/yr - $230K/yr

Compass Pathways plc is a biotechnology company focused on improving mental health through innovative treatments. The Principal Scientist, Clinical Sciences is responsible for leading scientific and operational excellence in clinical studies, ensuring compliance with regulatory standards and patient-centered design.

BiotechnologyHealth CareLife ScienceMental HealthPersonal HealthWellness

Growth Opportunities

No H1B

Responsibilities

Maintain scientific oversight during study execution, supporting medical monitoring, protocol deviations/clarifications, Clinical Study Report quality, and interpretation of clinical signals across programs

Accountable for compliance with ethical and scientific standards, regulatory requirements, and the Compass Quality Management System, ensuring participant safety, data integrity, and accuracy throughout the trial process

Lead SOPs, templates, and scalable processes that implement quality and velocity across the development portfolio

Contribute to cross-functional readiness for key milestones (database lock, regulatory interactions), establishing operating rhythms and documentation standards consistent with Compass values and governance

Lead authorship and scientific integrity of clinical protocols, synopses, amendments, and key trial documents, integrating disease biology, patient journey insights, and regulatory feedback for psychiatric indications

Define study objectives, endpoints, inclusion/exclusion criteria, and statistical considerations in partnership with Statistics, aligning with target product profile and pivotal-readiness standards

Drive cross-functional protocol development forums, ensuring timely input from all relevant functions, and resolving scientific and operational trade-offs with clear decision logs

Ensure evidence plans anticipate payer and access needs by partnering with HEOR/RWE to harmonize endpoints, PROs, and real-world relevance from protocol inception

Champion patient-centric design, incorporating feasibility data, KOL feedback, and ethical considerations into procedures, visit schedules, and burden-reduction strategies

Qualification

PhD in neuroscienceClinical development experienceProtocol authorshipCNS experienceScientific writingData interpretationCross-functional collaborationMission-aligned contributorCommunication skills

Required

PhD in neuroscience, pharmacology, or related life sciences field, or MD/PharmD with equivalent clinical development experience

Required industry experience in biopharma/biotech clinical development with demonstrated leadership in protocol authorship and late-stage study design

Proven capability to translate biology and patient insights into clear study objectives, endpoints, and operationally feasible designs

Strong cross-functional collaboration; skilled at guiding teams through complex scientific choices and change

Excellent scientific writing, data interpretation, and communication skills, with a track record of high-quality clinical documents and timely milestone delivery

Mission-aligned, inclusive contributor who reflects Compass values and a wellbeing-first, stigma free culture