Revolution Medicines · 13 hours ago
Associate Director, Medicinal Chemistry
Redwood City, California, United States
Full-time
Hybrid
Lead/Staff, Director/Executive
$186K/yr - $233K/yr
5+ years expRevolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies for RAS-addicted cancers. The Associate Director of Medicinal Chemistry will lead early hit discovery efforts, manage medicinal chemistry strategies, and collaborate with cross-functional teams to deliver high-quality anti-cancer drug candidates.
Health CareLife ScienceMedical
Responsibilities
Lead and execute medicinal chemistry strategies for early-stage discovery programs, including target validation, hit finding, and hit-to-lead optimization
Design and drive efficient, hypothesis-driven Design–Make–Test–Analyze (DMTA) cycles to deliver differentiated small-molecule leads and development candidates
Identify key scientific risks, define mitigation strategies, and provide data-driven recommendations at project decision points
Collaborate closely with cross-functional partners in Screening Sciences, Discovery Biology, Computational Chemistry, DMPK, Pharmacology, and CMC to ensure integrated project progression and timely delivery
Communicate project strategy, data, and conclusions clearly to cross-functional teams and senior leadership
Provide scientific oversight and direction for external chemistry CRO activities to ensure quality, efficiency, and alignment with program objectives
Contribute to invention disclosures, patent filings, and external scientific publications
Champion best practices in medicinal chemistry and continuously improve scientific and operational effectiveness
Manage, coach, and mentor medicinal chemists, providing technical guidance, performance feedback, and career development support
Foster a culture of scientific excellence, accountability, and collaboration consistent with RevMed’s Integrated Discovery Research vision
Qualification
Required
Ph.D. degree in chemistry
Minimum of 5 years of experience in the pharmaceutical/biotech industry with a track record of scientific innovation in the medicinal chemistry discipline
Working knowledge of modern medicinal chemistry and drug discovery approaches
Track record of involvement in identifying a development candidate with a deep understanding of hit generation, hit-to-lead, structure-based drug design and lead optimization
Experience managing scientific collaborations and external CRO resources
Strong problem-solving skills with sound technically driven decision-making
Effective written and verbal communication skills and interpersonal
An innovative team-player and leader with capacity to be effective in a dynamic and fast-paced environment
Preferred
Experience in beyond Rule-of-Five (bRo5) small-molecule drug discovery
Experience in oncology drug discovery research
Experience in targeting historically undruggable targets through approaches such as covalent inhibitors, macrocycles, molecular glues, and other alternative modalities
Demonstrated leadership experience, including mentoring and developing scientists within multidisciplinary teams
Benefits
Competitive cash compensation
Robust equity awards
Strong benefits
Significant learning and development opportunities
Company
Revolution Medicines
Revolution Medicines is an innovative and dynamic organization of expert biologists, chemists, pharmacologists, clinical scientists.
501-1000 employees
H1B Sponsorship
Revolution Medicines has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (13)
2024 (18)
2023 (15)
2022 (8)
2021 (1)
2020 (2)
Funding
Current Stage
Public CompanyTotal Funding
$2.25BKey Investors
Royalty PharmaBoxer CapitalNextech Invest
2025-06-24Post Ipo Debt· $250M
2024-12-02Post Ipo Equity· $750M
2023-03-02Post Ipo Equity· $323.6M
Leadership Team
Luan Wilfong
Chief Human Resources Officer
Steve Kelsey
President
Recent News
Pharmaceutical Technology
2026-01-13
Company data provided by crunchbase