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10x Genomics · 3 hours ago

Senior Manufacturing Engineer (Contract Position)

Pleasanton, California, USA HQ

Contract

Onsite

Senior Level

5+ years exp

10x Genomics is dedicated to accelerating our understanding of biology and enabling scientists to advance their research. They are seeking a Contract Senior Manufacturing Engineer to support both New Product Introduction and Sustaining Engineering, collaborating with various teams to enhance product performance and manufacturability.

Biotechnology

H1B Sponsor Likely

Responsibilities

Lead and support manufacturing engineering efforts for both NPI and sustaining projects, collaborating with R&D, manufacturing, and service teams to bring new instrument platforms from prototype through pilot builds to full-scale production

Drive continuous improvement initiatives by investigating field performance issues, analyzing return material data, and implementing design and process enhancements

Partner with contract manufacturers and internal teams to conduct root cause analysis and implement corrective/preventive actions (CAPAs) for in-production and fielded instruments

Conduct failure analysis and reliability testing (e.g., MTBF/MTTR) to validate long-term performance and support design decisions

Identify and implement changes to improve product cost, quality, and manufacturability using DFM, DFA, and lean manufacturing principles

Perform hands-on work to troubleshoot, evaluate, and iterate on mechanical, optical, and electromechanical subsystems

Maintain and manage engineering documentation, including BOMs in ERP/PLM systems, risk assessments, and change orders

Interface with quality and compliance teams to ensure adherence to design controls, regulatory standards, and safety requirements

Qualification

Mechanical EngineeringSolidWorksRoot Cause AnalysisReliability EngineeringNPI ProcessesDFM/DFATroubleshootingDocumentation ManagementPythonOracle ERPJiraConfluenceArena PLMCommunication SkillsOrganizational SkillsCollaboration

Required

Bachelor's degree in Mechanical, Optical, or related Engineering field with 8+ years of relevant experience, or Master's degree with 5+ years of experience in automation or instrumentation development

Proficient in SolidWorks for 3D CAD modeling, design analysis, and creating detailed mechanical drawings

Experience supporting both new product development and sustaining efforts in a fast-paced engineering or manufacturing environment

Proven ability to conduct structured root cause analysis and drive cross-functional resolution of mechanical and system-level issues

Familiar with reliability engineering concepts and design verification/validation testing

Ability to work collaboratively across functions including R&D, operations, supply chain, and field service

Strong organizational and communication skills; capable of balancing multiple priorities and presenting findings clearly

Preferred

Experience in NPI processes, pilot builds, and design transfer to contract manufacturers

Strong background in mechanical design for complex capital equipment, ideally including optics, motion systems, and fluidics

Familiarity with optical subsystems and precision electromechanical assemblies

Hands-on experience troubleshooting liquid handling or programmed automation systems

Experience with DFM/DFT/DFA and process validation in regulated environments (e.g., ISO 13485, FDA)

Proficient in tools like Python, Jira, Confluence, Oracle ERP, and Arena PLM

Knowledge of risk management tools (e.g., FMEA) and reliability metrics (e.g., MTBF, MTTR)

Comfortable managing BOMs, ECOs, and documentation in a structured product development environment

Company

10x Genomics

Glassdoor3.5

Cells are the basic unit of life.

Founded in 2012

Pleasanton, California, US

1001-5000 employees

http://10xgenomics.com

H1B Sponsorship

10x Genomics has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2025 (41)

2024 (40)

2023 (35)

2022 (52)

2021 (34)

2020 (16)