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Climb Bio · 2 days ago

Sr. Director, Clinical Pharmacology

Wellesley, MA

Full-time

Hybrid

Director/Executive

8+ years exp

Climb Bio is a clinical-stage biotechnology company developing therapeutics for patients with immune-mediated diseases. They are seeking an experienced Sr. Director, Clinical Scientist who will be responsible for the design, execution, and interpretation of clinical studies in support of Climb Bio’s development programs.

BiotechnologyHealth CareNeurosciencePharmaceutical

Responsibilities

Lead or co-lead the design and authoring of clinical protocols, amendments, and associated scientific documents

Define study objectives, endpoints, dose rationale, eligibility criteria, and biomarker strategies in collaboration with Medical Directors

Ensure studies are scientifically sound and aligned with the target product profile

Actively participate in study data review, including safety, PK/PD, and biomarker data

Partner with key business stakeholders to shape analyses and interpret outputs

Contribute to dose escalation and study design discussions and internal data review meetings

Work in close partnership with Medical Directors to support study execution and clinical decision making

Collaborate with Clinical Operations to balance scientific rigor with operational feasibility

Partner with key business stakeholders to ensure continuity across development stages

Contribute to regulatory documents and interactions, including briefing materials and responses

Support investigator engagement, KOL discussions, and advisory boards as a scientific representative

Contribute to development of best practices, templates, and standards for clinical science deliverables

Serve as a trusted scientific advisor to the CMO and development team

Qualification

Clinical developmentProtocol authoringData interpretationRegulatory submissionsTranslational acumenComplex datasetsCommunication skillsCollaborative environment