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Precise Systems, Inc. · 3 days ago

Mass Spectrometry Based Multi-Omics Research Scientist

Aberdeen Proving Ground, MD

Full-time

Onsite

Mid, Senior Level

$89K/yr - $129K/yr

5+ years exp

Precise Systems, Inc. is a solutions-based company focused on innovation to support warfighters. They are seeking a Multi-Omics Scientist to develop, optimize, and implement mass spectrometry methods for detecting and quantifying infectious disease pathogens.

ComputerConsumer ElectronicsInformation TechnologyRoboticsSoftware

Growth Opportunities

No H1B

Security Clearance Required

U.S. Citizen Only

Responsibilities

Collaborate with a team to design, test, and deliver liquid chromatography coupled with mass spectrometry (LC-MS) methods to detect proteins, metabolites and lipids

Develop detection methods in the laboratory, optimize and streamline them for field use, troubleshoot processes and equipment, train and prepare for field demonstrations

Curate unique methods to extract both metabolites and lipids from simple and complex mediums such as cell lysates, tissues, bacteria, hair, soil, and other environmental substrates/surfaces

Execute standard biophysical techniques for bottom-up proteomics including protein quantification, protein extraction/isolation, reduction, alkylation, enzymatic digestion, peptide quantification, and peptide concentration normalization

Validate and optimize metabolomics and lipidomics workflows for MS analysis including sample preparation techniques like BAW, Bligh-Dyer, MTBE, and Matyash extraction methods

Analyze data generated from multi-omics experimentation including database sequence searching, algorithm etic interpretation of the data sets, and visualization

Perform metabolite purification and quantification procedures such, solid phase extraction, and C18 clean up strategies followed by a Dansylation assay and metabolite concentration normalization

Utilize portable and high-resolution mass spectrometers namely, Thermo Eclipse, Bruker timsTOF Ultra 2, Bruker timsTOF HT, and Agilent QQQ

Utilize other platforms to support MS acquisition including an Evosep LC, Thermo Ultimate, LC, and Thermo Vanquish LC

Develop workflows, optimize and streamline for use in field environments, and troubleshoot processes and equipment to train and prepare for field demonstrations

Typical samples could be simple or complex, individual or pooled, and require targeted and untargeted approaches

Samples may be of human origin or BSL2 near neighbor, simulant, or surrogate pathogens of military relevance

The laboratory is well supported, with unique capabilities, and opportunities for publication and presentations

Qualification

Mass SpectrometryLiquid ChromatographyMulti-Omics StrategiesData AnalysisBiophysical TechniquesTroubleshootingTrainingTeam Collaboration

Required

PhD in Biochemistry, Chemistry, Biology, Molecular Biology or a related field

5 years' experience in standard mass spectrometric methods for the analysis and detection of small molecules, metabolites, lipids, proteins/peptides

Must be able to obtain and maintain a Secret security clearance

Due to the sensitivity of customer-related requirements, U.S. Citizenship is required

Preferred

Extensive experience in MS based multi-omics strategies as well as data analysis

Benefits

Health insurance

Life and accidental death and dismemberment coverage

Disability insurance

Retirement plans

Holiday pay

Employee-managed leave

Professional growth opportunities

Company

Precise Systems, Inc.

As a solutions-based company, Precise Systems is focused on innovation in support of the warfighters and aligning our expertise to deliver the highest quality of service.

Founded in 1990

Lexington Park, Maryland, USA

1001-5000 employees