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Exact Sciences · 12 hours ago

Senior Bioinformatician - Genetics

San Diego, CA

Full-time

Onsite

Mid, Senior Level

$119K/yr - $178K/yr

5+ years exp

Exact Sciences is helping change how the world prevents, detects and guides treatment for cancer. The Sr. Bioinformatician plays a critical role in supporting clinical and research operations through advanced data analysis, pipeline management, and regulatory compliance, while leading complex projects and mentoring junior staff.

BiotechnologyHealth DiagnosticsManufacturingMedical

No H1B

Responsibilities

Lead and execute complex bioinformatics analyses across multiple platforms and studies

Diagnose and resolve pipeline errors; troubleshoot QC issues and sequencing anomalies

Develop and maintain tools for variant calling, annotation, and artifact detection, incorporating new approaches and technologies

Review and interpret intermediate and final test results, ensuring analytic performance meets regulatory standards

Perform advanced case investigations for discordant results, contamination, and false positives

Coordinate data delivery for clinical studies and clinical reporting

Stay current with industry advancements, tools, and techniques; apply innovative solutions to bioinformatics challenges

Serve as Testing Personnel under CLIA and NYS regulations

Participate in verification and validation studies for new assays and workflow improvements

Assist with regulatory inspections and implement corrective and preventive actions (CAPAs)

Review and revise SOPs; ensure documentation aligns with current regulatory expectations

Evaluate proficiency testing data and contribute to regulatory submissions

Act as bioinformatics lead on cross-functional projects involving R&D, clinical, and laboratory stakeholders

Mentor and train junior bioinformatics staff; sign off on training and competencies

Present complex findings and strategic recommendations to laboratory management and executive stakeholders

Foster consensus and collaboration across teams, leveraging a strong understanding of how bioinformatics integrates with assay development, data science, and IT infrastructure

Ability to work independently and collaboratively in a fast-paced, regulated environment

Strong attention to detail and commitment to data integrity

Uphold company mission and values through accountability, innovation, integrity, quality, and teamwork

Support and comply with the company’s Quality Management System policies and procedures

Maintain regular and reliable attendance

Ability to act with an inclusion mindset and model these behaviors for the organization

Ability to work on a mobile device, tablet, or in front of a computer screen and/or perform typing for approximately 90% of a typical working day

Ability to travel up to 5% of working time away from work location, may include overnight/weekend travel

Qualification

BioinformaticsNext-Generation SequencingRegulatory ComplianceLinux-based HPCStatistical SoftwareVariant InterpretationProject ManagementCommunication SkillsProblem-Solving SkillsAttention to Detail

Required

PhD in bioinformatics, computational biology, computer science, or field as outlined in the essential duties; or Master's degree plus 4 years of experience in lieu of a PhD; or Bachelor's degree plus 6 years of experience in lieu of a PhD

5+ years of experience in bioinformatics and/or bioinformatics operations in industry or academia

3+ years in a regulated environment (e.g., medical device, IVD, biotech, or pharma)

Proficiency in Linux-based HPC or cloud computing environments

Proficiency writing custom code with the ability to adapt to commonly used languages

Expertise in NGS and genomics

Experience with statistical software (e.g., R, JMP)

Strong documentation, communication, and problem-solving skills

Demonstrated ability to perform the essential duties of the position with or without accommodation

Applicants must be currently authorized to work in country where work will be performed on a full or part-time basis. We are unable to sponsor or take over sponsorship of employment visas at this time