Revolution Medicines · 1 day ago
Scientist II, DMPK
Redwood City, California, United States
Full-time
Hybrid
Entry, Mid Level
$132K/yr - $166K/yr
2+ years expRevolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies for RAS-addicted cancers. The DMPK Scientist will play a crucial role in the Drug Metabolism and Pharmacokinetics team, executing metabolite identification studies and supporting regulatory submissions.
Health CareLife ScienceMedical
Responsibilities
Design and execute in vitro and in vivo metabolite identification studies using liver microsomes, hepatocytes, recombinant enzymes, and biological samples (blood, plasma, tissue, urine, bile, etc.), and perform metabolite profiling and structural elucidation
Characterize major, unique, or disproportionate metabolites to support candidate selection, MIST (Metabolites in Safety Testing) analysis, and metabolite regulatory strategy
Design and perform mechanistic studies to understand metabolic pathways and enzyme kinetics; work with pharmaceutical product teams to characterize drug degradation products and impurities
Develop and apply PBPK models to predict human DDI risk potential using preclinical dataset; support regulatory interactions related to PBPK-based DDI modeling strategies
Author and review DMPK sections of regulatory submissions and respond to questions from regulatory agencies
Build and maintain strong collaborative partnerships across functional areas, e.g., Discovery research, Clinical Pharmacology, Medicinal Chemistry, Pharmaceutical Development, Toxicology, and Translational Research
Qualification
Required
A highly motivated individual with a PhD in Pharmaceutical Sciences, Chemistry, Biochemistry, or related field, with > 2 years of experience after graduation
Demonstrated hands-on experience in metabolite profiling using high resolution mass spectrometry
Solid understanding of drug metabolism, pharmacokinetics, and ADME principles
Excellent verbal and written communication, problem-solving and critical thinking skills
Ability to independently design experiments, analyze data, and communicate results
Preferred
Prior experience with oncology drug discovery is preferred
Familiar with PBPK modeling software (e.g. WinNonlin, Simcyp, Gastroplus)
Effective communication and documentation skills
Benefits
Competitive cash compensation
Robust equity awards
Strong benefits
Significant learning and development opportunities
Company
Revolution Medicines
Revolution Medicines is an innovative and dynamic organization of expert biologists, chemists, pharmacologists, clinical scientists.
501-1000 employees
H1B Sponsorship
Revolution Medicines has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (13)
2024 (18)
2023 (15)
2022 (8)
2021 (1)
2020 (2)
Funding
Current Stage
Public CompanyTotal Funding
$2.25BKey Investors
Royalty PharmaBoxer CapitalNextech Invest
2025-06-24Post Ipo Debt· $250M
2024-12-02Post Ipo Equity· $750M
2023-03-02Post Ipo Equity· $323.6M
Leadership Team
Luan Wilfong
Chief Human Resources Officer
Steve Kelsey
President
Recent News
Pharmaceutical Technology
2026-01-13
Company data provided by crunchbase