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Boehringer Ingelheim · 9 hours ago

Senior Principal Scientist, Portfolio In silico Evidence Lead, Computational Biology

United States

Full-time

Remote

Senior Level, Lead/Staff

$170K/yr - $269K/yr

7+ years exp

Boehringer Ingelheim is seeking a highly motivated and accomplished Senior Principal Scientist to drive in silico evidence generation and advance novel therapeutic candidates. This role will leverage advanced computational approaches to elucidate mechanisms of action and facilitate late-stage project transitions in relevant patient segments.

BiotechnologyHealth CareMedicalPharmaceutical

Comp. & Benefits

No H1B

Responsibilities

In Silico Evidence Generation: Drive the generation of robust in silico evidence packages to support the progression of NTCs through critical development milestones

Bioinformatics Project Leadership: Lead and execute bioinformatics projects to deliver innovative NTC MoA insights, with a particular emphasis on dermatological applications

Advanced Computational Approaches: Leverage single and spatial omics technologies, machine learning/AI techniques, biological knowledge, and deep disease understanding to build compelling in silico evidence packages

Clinical Biomarker & Safety/Toxicity Contribution: Contribute to clinical biomarker discovery efforts and/or data-driven safety and toxicity assessments

Cross-Functional Collaboration: Work closely with colleagues in I&R, as well as in vitro and in vivo biologists, to integrate computational findings with experimental data

Omics-Based Approach Development: Develop and implement novel omics-based computational approaches to address key challenges in drug development

Drug Development Contribution: Apply computational expertise to various stages of the drug development pipeline, from target identification to late-stage clinical development

Qualification

BioinformaticsComputational BiologyMachine LearningImmunologyDermatologyRheumatologyOmics TechnologiesClinical Biomarker DiscoveryData-Driven Safety AssessmentCommunication SkillsCollaboration Skills

Required

Ph.D. in Bioinformatics, Computational Biology, Immunology, Molecular Biology, or a related discipline with 7 or more years of relevant post-doctoral and/or industry experience in drug discovery and development, with at least three (3) years of experience in drug discovery

Demonstrated expertise in understanding complex disease mechanisms, particularly within immunology, dermatology, and/or rheumatology

Expertise in bioinformatics, including the analysis of large-scale biological datasets (e.g., single-cell RNA-seq, spatial transcriptomics, genomics, proteomics)

Proficiency in machine learning and artificial intelligence techniques for biological data analysis

Strong understanding of immunology and disease mechanisms, particularly in the context of dermatology and rheumatology

Experience collaborating with experimental biologists (in vitro and in vivo) to design experiments and interpret results

Demonstrated ability to translate complex computational findings into clear and actionable insights for drug development teams

Excellent communication, interpersonal, and presentation skills

Proven ability to work independently and as part of a highly collaborative, multidisciplinary team

Provides expert-level scientific and bioinformatics expertise within the area(s) of biology and human disease addressed by the TA

Knowledge of current key datasets, therapeutic landscape and demographic/epidemiological considerations within TA is required

Preferred

Experience with clinical biomarker discovery or data-driven safety & toxicity assessment

Familiarity with regulatory requirements and guidelines in drug development

Prior experience in dermatology and rheumatology research

Benefits

Role specific variable or performance-based bonus and or other compensation elements

Company

Boehringer Ingelheim

Glassdoor4.2

Boehringer Ingelheim is a group of pharmaceutical companies that focuses on prescription medicines and animal health. It is a sub-organization of Boehringer Ingelheim.

Founded in 1885

Ingelheim Am Rhein, Rheinland-Pfalz, DEU

10001+ employees