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Boehringer Ingelheim · 8 hours ago

Senior Principal Scientist, Portfolio In silico Evidence Lead, Computational Biology

Ridgefield, CT

Full-time

Onsite

Senior Level, Lead/Staff

$170K/yr - $269K/yr

7+ years exp

Boehringer Ingelheim is seeking a highly motivated and accomplished Senior Principal Scientist to drive in silico evidence generation and advance novel therapeutic candidates. This pivotal role will be instrumental in advancing understanding of disease mechanisms and driving drug discovery efforts for new dermatological and rheumatological indications.

BiotechnologyHealth CareMedicalPharmaceutical

Comp. & Benefits

H1B Sponsor Likely

Responsibilities

Drive the generation of robust in silico evidence packages to support the progression of NTCs through critical development milestones

Lead and execute bioinformatics projects to deliver innovative NTC MoA insights, with a particular emphasis on dermatological applications

Leverage single and spatial omics technologies, machine learning/AI techniques, biological knowledge, and deep disease understanding to build compelling in silico evidence packages

Contribute to clinical biomarker discovery efforts and/or data-driven safety and toxicity assessments

Work closely with colleagues in I&R, as well as in vitro and in vivo biologists, to integrate computational findings with experimental data

Develop and implement novel omics-based computational approaches to address key challenges in drug development

Apply computational expertise to various stages of the drug development pipeline, from target identification to late-stage clinical development

Qualification

BioinformaticsComputational BiologyMachine LearningOmics TechnologiesClinical Biomarker DiscoveryImmunology ExpertiseData AnalysisCommunication SkillsInterpersonal SkillsTeam Collaboration

Required

Ph.D. in Bioinformatics, Computational Biology, Immunology, Molecular Biology, or a related discipline with 7 or more years of relevant post-doctoral and/or industry experience in drug discovery and development, with at least three (3) years of experience in drug discovery

Demonstrated expertise in understanding complex disease mechanisms, particularly within immunology, dermatology, and/or rheumatology

Expertise in bioinformatics, including the analysis of large-scale biological datasets (e.g., single-cell RNA-seq, spatial transcriptomics, genomics, proteomics)

Proficiency in machine learning and artificial intelligence techniques for biological data analysis

Strong understanding of immunology and disease mechanisms, particularly in the context of dermatology and rheumatology

Experience collaborating with experimental biologists (in vitro and in vivo) to design experiments and interpret results

Demonstrated ability to translate complex computational findings into clear and actionable insights for drug development teams

Excellent communication, interpersonal, and presentation skills

Proven ability to work independently and as part of a highly collaborative, multidisciplinary team

Provides expert-level scientific and bioinformatics expertise within the area(s) of biology and human disease addressed by the TA

Knowledge of current key datasets, therapeutic landscape and demographic/epidemiological considerations within TA is required

Must be legally authorized to work in the United States without restriction

Must be willing to take a drug test and post-offer physical (if required)

Must be 18 years of age or older

Preferred

Experience with clinical biomarker discovery or data-driven safety & toxicity assessment

Familiarity with regulatory requirements and guidelines in drug development

Prior experience in dermatology and rheumatology research

Benefits

Role specific variable or performance-based bonus

Other compensation elements

Company

Boehringer Ingelheim

Glassdoor4.2

Boehringer Ingelheim is a group of pharmaceutical companies that focuses on prescription medicines and animal health. It is a sub-organization of Boehringer Ingelheim.

Founded in 1885

Ingelheim Am Rhein, Rheinland-Pfalz, DEU

10001+ employees

https://www.boehringer-ingelheim.com/

H1B Sponsorship

Boehringer Ingelheim has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

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Trends of Total Sponsorships

2025 (13)

2024 (4)

2023 (11)

2022 (7)

2021 (17)

2020 (1)