iBio, Inc. · 3 weeks ago
Principal Scientist, Protein Sciences
San Diego, CA
Full-time
Onsite
Senior Level, Lead/Staff
$133K/yr - $177K/yr
5+ years expiBio, Inc. is a preclinical stage biotechnology company focused on leveraging Artificial Intelligence for developing precision antibodies. They are seeking a Principal Scientist, Protein Sciences to lead the protein sciences group and drive therapeutic antibody development, particularly in bispecific formats.
Biotechnology
Responsibilities
Drive the design, engineering, and optimization of therapeutic antibodies, with a strong emphasis on bispecific formats and developability considerations
Perform comprehensive antibody characterization using methods such as ELISA, SPR, HPLC, BLI, and related assays
Oversee mammalian expression systems and provide leadership in protein purification and manufacturability testing
Lead, mentor, train, and manage members of the Protein Sciences group, including Scientists and Research Associates
Collaborate closely with cross-functional teams to ensure seamless progression of programs from platform discovery through in vivo proof-of-concept studies and into development
Communicate research findings effectively to internal stakeholders, senior leadership, external partners, and the broader scientific community as needed
Contribute to regulatory documentation, support development, and ensure adherence to industry standards and best practices
Drive innovation and intellectual property generation, including publications and patents where appropriate
Stay current with scientific literature and emerging technologies to continuously strengthen the company’s protein sciences capabilities
Qualification
Required
Extensive hands-on experience with antibody discovery, engineering, and development, including demonstrated leadership of antibody programs in a biotech or pharmaceutical setting
Proven expertise with multiple bispecific antibody formats, with a strong track record of assessing and guiding developability
Deep technical experience in mammalian protein expression, purification, and analytical characterization using standard assays (e.g., ELISA, SPR, HPLC, BLI)
Experience with antibody fusions, Fc-fusions, and conjugation to antibodies is highly desirable
Demonstrated ability to integrate deep knowledge in at least one disease area to shape and advance therapeutic programs
Industry experiences advancing biologic therapeutics from discovery through development, with contributions to clinical candidates
Successful track record of leading and mentoring scientific teams, as well as managing external collaborations with CROs or academic partners
Evidence of innovation and scientific leadership, including patents, publications, or conference presentations
Bachelor's degree in Biochemistry, Biophysics, Molecular Biology, or related field and 10+ years of experience within the biotech/pharmaceutical industry; or, Master's degree in Biochemistry, Biophysics, Molecular Biology, or related field and 8+ years of experience within the biotech/pharmaceutical industry; or, PhD degree in Biochemistry, Biophysics, Molecular Biology, or related field and 5+ years of experience within the biotech/pharmaceutical industry
Strong critical thinking skills with proven expertise in antibody development, safety, and pharmacokinetics
Demonstrated success in working effectively with cross-functional project teams in fast-paced environments
Exceptional oral presentation and written communication skills
Strong analytical mindset with keen attention to detail and effective problem-solving skills
Excellent organizational and time-management skills
Benefits
Medical, Dental, and Vision Insurance Options
Flexible Time Off
Our company observes seven designated holidays each calendar year.
401(k) with Company Match as described in plan documents.
Life and Disability Insurance
Short-term and long-term disability insurance
Company
iBio, Inc.
iBio is a cutting-edge biotech company leveraging AI and advanced computational biology to develop next-generation biopharmaceuticals for cardiometabolic diseases, obesity, cancer and other hard-to-treat diseases.
11-50 employees
Funding
Current Stage
Early StageLeadership Team
Martin Brenner
CEO & CSO
Felipe Duran
Chief Financial Officer
Company data provided by crunchbase