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Johnson & Johnson Innovative Medicine · 14 hours ago

Distinguished Scientist, Translational Safety

Cambridge, MA

Full-time

Onsite

Lead/Staff

$164K/yr - $283K/yr

12+ years exp

Johnson & Johnson Innovative Medicine is committed to healthcare innovation and is seeking a Distinguished Scientist in Translational Safety. This role involves leading predictive toxicology initiatives in early drug discovery and collaborating with various teams to enhance predictive toxicity workflows.

Pharmaceuticals

Responsibilities

Lead efforts to build and refine robust high-throughput in vitro organ specific cellular screening workflows

Serve as the liaison between High throughput screening, Data Sciences, In Silico Modeling and Preclinical Safety Teams

In collaboration with External Scientific Innovation and Business Development, evaluate external environment to identify new technologies, platforms & CROs with novel, cutting edge applications for in vitro toxicology

Partner with members of Translation Safety & Discovery, Product Development and Supply (DPDS) functional groups to oversee the conversion of mechanistic cellular, molecular & biochemical toxicology assays into high throughput predictive screening assays

Function as a key member of Global Translational Safety Team partnering with global leads to establish strategic goals and objectives

Communicate screening plans and updates to leadership and multidisciplinary teams

Maintain toxicology expertise through collaborations within TPPIT & PSTS globally, DPDS, and through organizational associations, literature reviews, continuing education, and publications

Partner with Global Lead of Cellular & Molecular Toxicology, as well as Safety Pharmacology leads to establish strategic goals and objectives

Identify topics appropriate for internal and external scientific publication, author scientific publications, posters and or draft documents for official communication (i.e. Contributing Scientist Reports, weight of evidence packages)

Qualification

Predictive ToxicologyHigh Throughput ScreeningCellular ToxicologyDrug DiscoveryAI/ML ModelingSilico ToxicologyBoard Certification in ToxicologyScientific ResearchTeam CollaborationCommunication

Required

A minimum of a Ph.D. and postdoctoral work in Toxicology, Pharmacology, Biology or related field is required

A minimum of 2-5 years postdoctoral training with a total of 12+ years of relevant work experience is required

Demonstrated knowledge in designing and conducting mechanistic in vitro studies incorporating high throughput applications of cell-based models required

Experience with high throughput applications of organotypic models incorporating multiple cell types including immune cells required

Demonstrated knowledge of drug discovery and experience with drug modalities beyond small molecules required

Advanced knowledge of cellular and molecular toxicology and demonstrated experience driving projects to completion required

Track record of working collaboratively to solve sophisticated scientific problems required

Experience working on & leading highly matrixed, multi-disciplinary teams required

Must be highly motivated, curious, and organized individual with a team-oriented mentality who enjoys working in a fast-paced, dynamic environment, and working collaboratively across functions

Excellent written, visual, and oral communication skills