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Flagship Pioneering · 14 hours ago

Pioneering Medicines: Medical Director / Senior Medical Director, Clinical Development Lead

Cambridge, MA USA

Full-time

Hybrid

Mid Level

$205K/yr - $335K/yr

3+ years exp

Flagship Pioneering is focused on developing life-changing treatments for patients through innovative scientific platforms. The Clinical Development Lead will drive the transition of programs from research into early clinical development, shaping clinical strategies and integrating development plans across various teams and stakeholders.

FinanceFinancial ServicesVenture Capital

H1B Sponsor Likely

Responsibilities

Lead the design of early clinical development plans (through hPOC) for PM programs, in alignment with the Target Product Profile (TPP)

Collaborate closely with the senior clinical leaders, Project Leaders, Research, Strategy, and external advisors/KOLs to define and refine clinical hypotheses and development strategies

Integrate clinical plans with translational, nonclinical, and regulatory development strategies to enable seamless progression from exploratory studies to FIH trials

Partner with Research teams—including Pharmacology, Translational Sciences, and Nonclinical Development—to align research outputs with clinical objectives

Work with the Strategy Group to ensure clinical plans support the TPP and the overall program value proposition

Incorporate regulatory input, operational feasibility, and real-world data to ensure robust and executable development strategies

Collaborate with Project Management to develop integrated timelines, resource forecasts, and budget assumptions for incorporation into NewCo planning

Support the preparation and delivery of key materials for internal governance forums and Joint Steering Committees (JSCs) with external partners

Identify and address development risks and bottlenecks proactively; drive resolution across functional interfaces

Promote a culture of scientific rigor, accountability, agility, and open collaboration within project teams

Enhance cross-functional integration by facilitating communication, alignment, and shared ownership of development goals

Qualification

Physician ScientistClinical DevelopmentTranslational MedicineOncologyImmunologyMetabolic DiseasesLeadershipCommunication SkillsStrategic ThinkingCritical ThinkingAdaptability

Required

Physician Scientist: MD or MD with PhD with a robust scientific background

3+ years or more of post-graduate/post-residency experience in industry or academic clinical research

Strong understanding of early clinical development and translational medicine, mechanisms of disease, and patient care paradigms in relevant therapeutic areas (oncology, immunology and/or metabolic diseases preferred)

Demonstrated excellence in scientific rigor, operational decision making, risk mitigation, and innovation

Proven leadership and effective communication skills, with the ability to collaborate and convey strategic implications to diverse stakeholders

Excellent oral, written, and presentation skills for engaging stakeholders and fostering teamwork

Strong strategic thinking and critical thinking skills for identifying and addressing bottlenecks while optimizing cross-functional processes

Proactive and adaptable in demanding environments, with an operational mindset to improve efficiency and achieve strategic goals

Preferred

Medical residency and/or subspecialty fellowship training highly preferred

Benefits

Healthcare coverage

Annual incentive program

Retirement benefits

Broad range of other benefits

Company

Flagship Pioneering

Glassdoor3.3

Flagship Pioneering is a venture capital firm that invests in life sciences and healthcare companies.

Founded in 2000

Cambridge, Massachusetts, USA

501-1000 employees

http://flagshippioneering.com

H1B Sponsorship

Flagship Pioneering has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2025 (8)

2024 (4)

2023 (4)

2022 (4)

2021 (1)