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Allen Institute · 3 days ago

Scientist I - Alzheimer's Disease

Seattle, WA

Full-time

Hybrid

Mid Level

$86K/yr - $107K/yr

The Allen Institute is dedicated to advancing health and understanding life principles through innovative research. They are seeking a Scientist I to contribute to the Seattle Alzheimer’s Disease Brain Cell Atlas project by designing and executing experiments that enhance the understanding of Alzheimer’s disease through single-cell genomics and neuroanatomy.

Neuroscience

H1B Sponsored

Responsibilities

Contribute to the design and execution of large-scale single-cell genomics experiments

Participate in the development and testing of new single-cell methods and protocols

Optimize protocols for challenging samples , troubleshoot workflows for variable tissue quality, and evaluate tissue and sequencing library quality using standard metrics

Conduct basic analysis of single-cell genomics data, including benchmarking of new methods

Design and execute experiments to validate and extend computational results and generate novel biological insights

Present progress in group meetings and at scientific conferences, and contribute to peer-reviewed publications

Assist in management of tissue acquisition and sample tracking

Maintain meticulous experimental records to ensure reproducibility across tissue donors and adherence to best practices for tissue handling, biosafety, and data integrity

Actively contribute to a collaborative environment focused on scientific rigor and methodological innovation

Qualification

Single-cell genomicsMolecular neuroscienceAlzheimer's disease biologyHuman neuroanatomyExperimental researchData analysisCommunication skillsOrganizational skillsTeam collaboration

Required

PhD degree in Neuroscience, Molecular Biology, Genomics, or related field, or equivalent combination of degree and experience

Demonstrated experience conducting independent experimental research and interpreting complex biological data

Broad knowledge of and experience with single-cell genomics platforms

Preferred

Proficiency in independently conducting single-cell genomics assays

Hands-on experience with human postmortem or surgical brain tissue, including dissection, nuclei isolation, and nucleic acid extraction

Proven ability to troubleshoot complex molecular biology protocols and optimize workflows for variable sample quality

Basic experience or familiarity with multicolor flow cytometry

Basic familiarity with human neuroanatomy and willingness to expand anatomical knowledge

Proficiency in tissue sectioning, histological stains, and/or immunofluorescence panel optimization

Ability to capture and analyze high-quality images using confocal or fluorescence microscopy and to quantify results with ImageJ/Fiji, QuPath, or similar applications

Experience with Python and/or R for basic data analysis and visualization and an understanding of core single-cell data analysis concepts (e.g., QC, clustering, marker identification)

Working knowledge of AD pathology and molecular mechanisms of disease

Excellent communication skills and comfort working in large, multidisciplinary teams to pursue collaborative research goals

Strong quantitative and organizational skills, with attention to data quality and integrity

Benefits

Medical

Dental

Vision

Basic life insurance

401k plan

Paid time off

Company

Allen Institute

Glassdoor3.7

The Allen Institute is dedicated to answering some of the biggest questions in bioscience and accelerating research worldwide.

Founded in 2003

Seattle, Washington, USA

501-1000 employees

https://alleninstitute.org/

H1B Sponsorship

Allen Institute has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2025 (41)

2024 (33)

2023 (25)

2022 (26)

2021 (17)

2020 (7)