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Allen Institute · 4 hours ago

Senior Research Associate – High Throughput Screening

Seattle, WA

Full-time

Onsite

Mid, Senior Level

$92K/yr - $114K/yr

6+ years exp

The Allen Institute is dedicated to unlocking the complexities of bioscience to improve human health. They are seeking a Senior Research Associate to work in their artificial intelligence powered lab, focusing on high throughput screening and optimization of workflows in biological models.

Neuroscience

H1B Sponsored

Responsibilities

Develop advanced high throughput screen capabilities in multicellular models, preferably with single cell readout (e.g. mouse in vivo, gastruloids, embryoid bodies, teratomas)

Design validation experiments to benchmark performance of synthetic enhancer design AI models

Maintain and propagate human cell lines, optimize and perform plasmid DNA transfections and viral transductions

Perform advanced genomics protocols (e.g., custom amplicon sequencing, RNA-seq, single cell RNA-seq, ATAC-seq)

Independently execute molecular biology protocols, including molecular cloning, flow cytometry, quantitative PCR, ddPCR

Troubleshoot technical barriers in the generation of high quality NGS libraries, from library delivery to cell lines through NGS library generation

Review and analyze data, participating in quality control and troubleshooting of processes and results

Contribute to the development of new protocols as needed

Present results and summarize progress to help frame internal decision-making

Comply with SOPs, good laboratory practices, and regulatory requirements

Adhere to a team schedule and individual time management

Maintain accurate laboratory documentation using established methods

Other duties as assigned

Qualification

High throughput screeningMolecular biology protocolsGenomics protocolsCell culture techniquesNucleic acid sequencingData analysisTeam collaborationTime management

Required

Bachelor's degree in Cell Biology, Genetics, Synthetic Biology, Bioengineering, Genomics, Molecular Biology, Bioinformatics, or related field

6 years of relevant experience

Develop advanced high throughput screen capabilities in multicellular models, preferably with single cell readout (e.g. mouse in vivo, gastruloids, embryoid bodies, teratomas)

Design validation experiments to benchmark performance of synthetic enhancer design AI models

Maintain and propagate human cell lines, optimize and perform plasmid DNA transfections and viral transductions

Perform advanced genomics protocols (e.g., custom amplicon sequencing, RNA-seq, single cell RNA-seq, ATAC-seq)

Independently execute molecular biology protocols, including molecular cloning, flow cytometry, quantitative PCR, ddPCR

Troubleshoot technical barriers in the generation of high quality NGS libraries, from library delivery to cell lines through NGS library generation

Review and analyze data, participating in quality control and troubleshooting of processes and results

Contribute to the development of new protocols as needed

Present results and summarize progress to help frame internal decision-making

Comply with SOPs, good laboratory practices, and regulatory requirements

Adhere to a team schedule and individual time management

Maintain accurate laboratory documentation using established methods

Other duties as assigned

Preferred

Master's degree in Cell Biology, Genetics, Synthetic Biology, Bioengineering, Genomics, Molecular Biology, Bioinformatics, or related field

8+ years of relevant experience

Experience in a TechBio setting where wet lab experiments primarily serve to build AI models

Experience optimizing pooled high throughput screening workflows

Experience performing molecular biology methods including molecular cloning (such as restriction cloning, Gibson Assembly, Golden Gate assembly, plasmid prep)

Experience cloning complex libraries is a plus

RNA isolation, DNA isolation, and PCR

Track-record of being an effective team member

Competence and ability to work in a molecular biology/cell culture laboratory

Experience with nucleic acid sequencing, especially custom amplicon sequencing

Experience performing cell biology methods including mammalian cell culture, murine embryonic stem cell culture, primary cell culture, nucleofection, and lipofection

Benefits

Medical

Dental

Vision

Basic life insurance

401k plan

Paid time off

Company

Allen Institute

Glassdoor3.7

The Allen Institute is dedicated to answering some of the biggest questions in bioscience and accelerating research worldwide.

Founded in 2003

Seattle, Washington, USA

501-1000 employees

https://alleninstitute.org/

H1B Sponsorship

Allen Institute has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

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Trends of Total Sponsorships

2025 (41)

2024 (33)

2023 (25)

2022 (26)

2021 (17)

2020 (7)