AstraZeneca · 1 week ago
Associate Director
Waltham, MA
Full-time
Onsite
Senior Level, Lead/Staff, Director/Executive
$135K/yr - $202K/yr
7+ years expAstraZeneca is seeking a highly motivated and independent Associate Director to join their In Vivo Pharmacology Team in Waltham, MA. The role involves leading research to evaluate the efficacy and mechanisms of action of small molecules in hematology-oncology, as well as collaborating with cross-functional teams to ensure timely generation and dissemination of critical program data.
BiopharmaBiotechnologyHealth CareMedicalPharmaceuticalPrecision Medicine
Responsibilities
Develop, design, conduct and analyze both in vivo and in vitro experiments to assess the function of candidate oncology drugs and dissect the mechanism of action of novel cancer therapeutics
Collaborate with cross-functional teams including representatives from Translational Medicine, DMPK, Pharmsci, and Safety
Work collaboratively with project leaders to ensure timely generation and dissemination of critical program data
Lead a cross-functional working group focused on development and optimization of heme in vivo models in addition to biomarker assays for analysis of in vivo samples
Stay up to date with relevant technical and intellectual scientific expertise in hematology biology, pharmacology and cancer modeling
Create, submit, and manage IACUC protocols, ensuring adherence to animal welfare regulations and institutional policies
Manage outsourced in vivo studies and vendor relationships, including coordination and oversight of CRO activities
Qualification
Required
Ph.D. with more than 7 years of research experience in the biotechnology or pharmaceutical industry, focused on small-molecule drug discovery and development
Proven ability to lead multiple programs with a strong in vivo strategy and execution
Clear, demonstrated depth in small-molecule in vivo pharmacology, including design and interpretation of combination strategies with both small and large molecules (e.g., antibodies, ADCs, TCEs), and an understanding of the principles that drive optimal therapeutic combinations
Hands-on experience establishing and executing hematologic oncology in vivo models, including subcutaneous and luciferase-tagged disseminated xenografts, disseminated PDX models, and studies in humanized mice
Track record delivering high-quality in vivo pharmacology data packages for small-molecule programs, encompassing rodent tumor model development, dose-range finding and tolerability, PK/PD, and efficacy studies
Working knowledge of in vitro techniques such as cell culture, molecular biology, immunoblotting, spectral flow cytometry, MSD, and ELISA to support in vivo hypotheses and mechanism-of-action studies
Excellent communication, organizational, presentation, and active listening skills
Demonstrated ability to drive, manage, execute, and present results for oncology small-molecule projects to project teams, stakeholders, and senior leadership, with flexibility and adaptability to align with AstraZeneca ways of working
Strong interpersonal skills with a history of delivery in collaborative, cross-functional environments
Experience managing direct reports and influencing/leading across a highly matrixed organization
Prior experience managing outsourced in vivo studies and vendor relationships, including coordination and oversight of CRO activities
Proven ability to create, submit, and manage IACUC protocols, ensuring adherence to animal welfare regulations and institutional policies
Subject-matter expertise in myeloma, lymphoma, and acute myeloid leukemia biology, including cancer progenitor cells and early hematopoietic transformation
Experience with small-animal imaging, including bioluminescence imaging (e.g., IVIS), to support longitudinal efficacy and biodistribution studies
Strong publication record, with contributions to peer-reviewed literature; industry-focused publications are highly desirable
Experience identifying, initiating, and managing collaborations with external key opinion leaders and academic/industry partners to expand internal capabilities and accelerate program objectives
Benefits
Short-term incentive bonus opportunity
Equity-based long-term incentive program (salaried roles)
Retirement contribution (hourly roles)
Commission payment eligibility (sales roles)
Qualified retirement program [401(k) plan]
Paid vacation and holidays
Paid leaves
Health benefits including medical, prescription drug, dental, and vision coverage
Company
AstraZeneca
AstraZeneca is a pharmaceutical company that discovers, develops, manufactures, and markets prescription medicines. It is a sub-organization of Investor.
10001+ employees
H1B Sponsorship
AstraZeneca has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2021 (2)
2020 (11)
Funding
Current Stage
Public CompanyTotal Funding
$5.26B2024-07-30Post Ipo Debt· $1.51B
2023-02-28Post Ipo Debt· $2.25B
2023-02-24Post Ipo Debt· $1.5B
Leadership Team
Pascal Soriot
Chief Executive Officer
Aradhana Sarin
Group CFO and Executive Director
Recent News
Essential Business
2026-01-24
2026-01-23
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