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Merck · 9 hours ago

Senior Scientist – Downstream Vaccines and Advanced Biotechnologies Process R&D

USA - Pennsylvania - West Point

Full-time

Onsite

Mid, Senior Level

$117K/yr - $184K/yr

3+ years exp

Merck is a leading company in the biotechnology sector, and they are seeking a Senior Scientist for their Vaccine and Advanced Biotechnologies Process R&D department. The role involves supporting downstream process development for vaccine programs, contributing scientifically and technically to bioconjugation process development, and collaborating with cross-functional teams.

BiotechnologyHealth CareMedicalPharmaceutical

Comp. & Benefits

No H1B

Responsibilities

Independent design, execute, and analyze process development experiments to maximize conjugate vaccine production processes, thereby de-risking later stage development and tech transfer

Leadership roles in downstream process design and development for conjugate vaccine candidates

Represent functional area in cross-functional and strategic teams engaged in vaccine development

Lead tech transfer of vaccine bioconjugation processes for clinical and commercial manufacture

Serve as scientific/technical mentor. Provide technical guidance in the various aspects of downstream bioprocess/bioconjugation development

Support strategic initiatives and innovation in the areas of vaccine and advanced biotechnology process development

Analysis of experiments through analytical techniques including HPLC, light scattering, and spectroscopy

Data interpretation and presentation, manuscript/patent preparation

Qualification

Downstream Bioprocess DevelopmentBioconjugation TechniquesCGMP ManufacturingStatistical Design of ExperimentsColumn ChromatographyData AnalysisLaboratory SafetyInterpersonal RelationshipsTeam CollaborationOrganizational Skills

Required

BS, MS or PhD in engineering or bio/chemical sciences: Chemical Engineering, Bioengineering, Biomedical Engineering, Chemistry, Biochemistry, Molecular Biology, Biotechnology

For BS candidates, at least six (6) years of experience in a pharmaceutical or biotechnology-related position

For MS candidates, at least three (3) years of experience in a pharmaceutical or biotechnology-related position

For PhD candidates, at least one (1) year of experience in a pharmaceutical or biotechnology-related position

Strong scientific and hands-on understanding of downstream bioprocess/bioconjugation unit operations, biotherapeutic and/or vaccine process development and sound understanding of scale-up principles

At least three (3) years of hands-on laboratory experience in downstream bioprocess/bioconjugation development

Prior experience with statistical design of experiments (DOE) and/or algorithmic process optimization

Strong understanding of, or hands-on experience in, cGMP manufacturing

Ability to work effectively both independently and in a team-focused environment

Well-developed organizational, record-keeping, and timeline/resource-mapping skills

Preferred

Experience with biomolecule conjugation (e.g., conjugate vaccines, antibody-drug conjugates), conjugation chemistry and downstream bioconjugate processing

Experience in leading aspects of technical development and mentoring others

Experience in authoring and reviewing CMC regulatory documentation

Experience with process and technology transfer