Aureka Biotechnologies, Inc. · 2 days ago
Assay Development Associate Scientist or Scientist
Irvine, CA
Full-time
Onsite
Mid, Senior Level
3+ years expAureka Biotechnologies is an AI-driven biotech startup focused on discovering and developing antibody therapeutics. They are seeking a highly motivated Associate Scientist or Scientist to join their Assay Development Team, where the candidate will design and execute assays to characterize antibody function and efficacy.
BiotechnologyPharmaceutical
Responsibilities
Design, optimize, and execute cell-based functional assays, including reporter assays, cytokine release, proliferation, and immune activation assays
Develop and perform biochemical and binding assays such as ELISA, AlphaLISA, BLI/Octet, or flow-based binding
Maintain and manipulate mammalian cell lines (adherent and suspension) for transient and stable expression systems
Process human PBMC or patient samples for biomarkers and efficacy evaluation
Collaborate with the in vivo team to design and analyze pharmacodynamic and efficacy studies, including biomarker and ex vivo functional assays
Process and analyze in vivo samples (e.g., serum, plasma, tissue homogenates) using immunoassays or bioanalytical techniques
Support high-throughput screening campaigns by establishing robust, automation-ready workflows
Collaborate across biology and computational teams to integrate assay data into Aureka’s AI-driven discovery pipeline
Analyze, interpret, and present experimental results in project meetings and internal reviews
Maintain accurate experimental documentation in ELN and ensure compliance with data integrity best practices
Qualification
Required
M.S. or Ph.D. in Cell Biology, Biochemistry, Immunology, Bioengineering, or a related discipline
For Associate Scientist: 3–5 years of relevant experience
For Scientist: 5+ years of experience in assay development, biologics discovery, and/or in vivo pharmacology
Proven expertise in antibiotics-free mammalian cell culture and cell-based functional assays and experienced with handling human primary cells in BSL2 environments
Hands-on experience with biochemical and biophysical assays (ELISA, AlphaLISA, Octet/BLI, or flow cytometry)
Familiarity with in vivo pharmacology workflows, including sample handling, PD biomarker analysis, and data interpretation
Strong data analysis and troubleshooting skills; proficiency with GraphPad Prism, FlowJo, or equivalent analysis/statistics tools
Excellent attention to detail, organization, and ability to design/manage multiple experiments in parallel
Strong interpersonal and communication skills, with the ability to work collaboratively in a cross-functional, fast-paced environment
Preferred
Experience with antibody or therapeutic protein characterization (agonism, antagonism, Fc effector, checkpoint signaling, and cytokine signaling)
Familiarity with rodent models of inflammation, autoimmunity, or metabolic disease (not necessarily direct handling)
Experience with assay automation or 384-well miniaturization
Benefits
Comprehensive healthcare coverage
Equity participation
Family leave
Paid time off
401(k) retirement plan
Company
Aureka Biotechnologies, Inc.
Aureka Biotechnologies is a biotech startup democratizing the pharmaceutical industry through our focused area of immunotherapeutic discovery.
11-50 employees
H1B Sponsorship
Aureka Biotechnologies, Inc. has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (1)
2024 (2)
Funding
Current Stage
Early StageTotal Funding
$33.37MKey Investors
5Y CapitalBioTools Innovator
2025-09-26Series A· $23.37M
2023-06-25Seed· $10M
2023-06-06Non Equity Assistance
Leadership Team
Weian Zhao
Founder and CEO
Alon Wellner
VP Biology and co-founder
Company data provided by crunchbase