Synthesize Bio · 11 hours ago
Principal Computational Biologist
Washington, United States
Full-time
Hybrid
Senior Level, Lead/Staff
$165K/yr - $190K/yr
5+ years expSynthesize Bio is an early stage startup using generative AI to fundamentally change life sciences research and accelerate the pace of biomedical discovery. The Principal Computational Biologist will lead computational efforts, develop internal tools, and collaborate with external partners to enhance AI systems in the life sciences domain.
Biotechnology
No H1B
Responsibilities
Work with external collaborators/partners as the computational lead and point-person
Develop internal tools (e.g., packages and analysis suites) in collaboration with other team members across the company (such as software engineers and AI researchers)
Imagine and pilot new use cases for our AI systems
Design validation studies for our AI systems
Author externally-facing communications (blog posts, conference abstracts)
Qualification
Required
Working in cross-functional teams (within and outside your organization) on applications of machine learning/AI to biomarker development and clinical trial design
Deep expertise designing and interpreting studies with gene expression and other omics data
Experience designing internal solutions for data science workflows (how to work reproducibly, collaborate, document, mentor junior team members)
The ideal candidate is someone who leads by example and can lead technical projects
Preferred
Experience managing and working with large datasets in the cloud (AWS, GCP)
Experience and perspective that empathizes with and represents the voices of biomedical research and development customers
Experience mentoring junior scientists in best practices and problem-solving including performing code reviews
5+ years post-academic training
Bioinformatics pipeline development and data infrastructure (we have other roles that specialize there)
Past experience leading and mentoring computational scientists is a positive, but this is an individual contributor role
Benefits
100% employer paid health insurance premiums, 50% dependents
401k plan access (non-matching)
Gym access for Seattle-based employees
Company
Synthesize Bio
Synthesize Bio uses AI to reduce data collection and analysis for a fraction of the cost in time, personnel, and materials.
11-50 employees
Funding
Current Stage
Early StageTotal Funding
$10MKey Investors
Madrona
2025-09-16Seed· $10M
Recent News
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