Apply on Employer Site

Janux Therapeutics · 15 hours ago

Clinical Biomarker Lead

San Diego, CA

Full-time

Onsite

Mid, Senior Level

$150K/yr - $163K/yr

4+ years exp

Janux Therapeutics is seeking a Clinical Biomarker Lead to join our Translational group and contribute hands-on in the development and execution of biomarker analysis plans and data analytics strategy for our early-stage oncology programs. This individual will develop critical insights from clinical trial data to inform strategic decision-making across Janux’s early phase portfolio.

BiotechnologyHealth DiagnosticsPharmaceuticalTherapeutics

Responsibilities

Lead internal biomarker data analysis efforts to support Janux’s oncology and autoimmune pipeline

Perform high throughput data analytics of pre-clinical, translational, and clinical datasets to identify and validate potential biomarkers of response/resistance to TRACTr, TRACIr, and/or ARM treatments

Integrate functional biological readouts with patient’s clinicopathological features to contribute to patient selection strategies for clinical programs

Identify, develop, and validate translational and clinical biomarker assays including Pharmacokinetics, immunogenicity (ADA and NAb assays), Pharmacodynamics, and predictive

Manage multiple CROs and maintain strong oversight on deliverables (proposals, timelines, experimental design, data analyses and reporting)

Prepare and present data. Collaborate with Biomarker and Translational teams to evaluate data analytic approaches and ensure meaningful insights in the delivery

Perform in-depth scientific literature review to help address critical questions relating to target biology, clinical relevance, and associated assays

Work cross-functionally with Research, Clinical and CMC teams to drive scientific programs and deliver critical insights to help inform decision-making across the portfolio

Qualification

BioinformaticsImmuno-oncologyBiomarker analysisRPythonData visualizationClinical PracticeAnalytical skillsCritical thinkingCommunication skills

Required

Ph.D. in Bioinformatics, Computational Biology, Immunology, or related scientific discipline with 4+ years of experience, preferably in an industry setting, with an emphasis in biomarker analysis or translational medicine

Strong understanding and experience working in immuno-oncology and/or solid tumor oncology with hands-on experience in designing, developing, and interpreting biomarker analysis

Proficiency in coding skills (e.g., R, Python) and strong working knowledge of bioinformatics databases and tools

Demonstrated ability to create impactful data visualization outputs and present meaningful insights

Experience with Good Clinical Practice (GCP) principles and studies transitioning into clinical trials

Competence in data analysis tools (Excel, GraphPad, R, Python)

Strong analytical and critical thinking skills with the ability to work in a fast-paced environment

Excellent written and oral communication skills

Work authorization: United States (Required)