Principal Machine Learning Engineer jobs in United States
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Hologic, Inc. · 9 hours ago

Principal Machine Learning Engineer

Hologic, Inc. is a company focused on delivering innovation in medical technology, particularly in breast and skeletal health. The Principal Machine Learning Engineer will design, develop, and deploy advanced AI algorithms for medical devices, specifically for breast cancer detection, ensuring technologies are clinically validated and impactful for patient outcomes.

BiotechnologyHealth CareHealth DiagnosticsWomen's
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Comp. & Benefits
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H1B Sponsor Likelynote

Qualification

Machine LearningDeep LearningComputer VisionPythonC++Model ValidationDeep Learning FrameworksCloud PlatformsMachine Learning PipelinesProblem-SolvingCommunication SkillsCollaborationLeadership

Required

Deep expertise in machine learning and deep learning, including supervised and self-supervised methods
Mastery of cutting-edge neural network architectures and training techniques
Strong foundation in computer vision, data preprocessing, feature engineering, and statistical analysis
Experience with model validation and performance benchmarking
Knowledge of software engineering best practices for building maintainable, scalable systems
Advanced programming in Python and C++, with proficiency in ML/data science libraries (e.g., Pandas, OpenCV, XGBoost, NumPy, SciPy)
Hands-on experience with deep learning frameworks (PyTorch, TensorFlow) and cloud platforms (AWS, Azure, GCP)
Proven ability to design, implement, and optimize machine learning pipelines for large-scale, high-dimensional 3D medical imaging data
Experience deploying and maintaining models in production environments
Strong problem-solving skills for translating clinical requirements into technical solutions
Excellent communication skills for technical documentation and stakeholder presentations
Effective cross-functional collaboration with engineers, clinicians, and product managers
Demonstrates leadership and initiative in driving complex projects from concept to deployment
Champions a collaborative, open, and success-driven team culture
Maintains high standards of integrity, accountability, and ethical decision-making
Adapts quickly to evolving technologies and priorities
Proactively seeks feedback and growth opportunities
Shows resilience and resourcefulness in technical and regulatory challenges
Prioritizes patient safety, data privacy, and compliance
Inspires teams through commitment to Hologic's mission and values

Preferred

Familiarity with FDA regulatory standards for AI in healthcare, DICOM format, digital breast tomosynthesis, and breast cancer pathology/diagnostic workflows

Benefits

Comprehensive training
Annual bonus scheme

Company

Hologic, Inc.

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We’re an innovative medical technology company whose purpose is to enable healthier lives everywhere, every day.

H1B Sponsorship

Hologic, Inc. has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (31)
2024 (20)
2023 (15)
2022 (32)
2021 (20)
2020 (14)

Funding

Current Stage
Public Company
Total Funding
$2.87B
2025-10-21Private Equity
2025-10-21Acquired
2025-07-15Post Ipo Debt· $2.42B

Leadership Team

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Stephen MacMillan
Chairman President & CEO
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Karen Harrington
Director Scientific Affairs
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Company data provided by crunchbase