Staff Software/Platform Engineer jobs in United States
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Twist Bioscience · 13 hours ago

Staff Software/Platform Engineer

positionSouth San Francisco, CA
timeFull-time
remoteOnsite
seniorityLead/Staff
money$206K/yr - $231K/yr
date8+ years exp

Twist Bioscience is a company focused on synthesizing genes to advance the genomics revolution. They are seeking an experienced Staff Engineer to maintain and evolve their multi-repository e-commerce platform and internal tooling, while serving as a technical leader in developing complex systems and influencing architectural decisions.

B2BBiotechnologyChemicalHealth CareLife Science
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H1B Sponsor Likelynote

Responsibilities

Design, develop, and maintain frontend and backend systems across multiple repositories
Apply systems thinking to reason about end-to-end architecture, dependencies, failure modes, scalability, and long-term maintainability
Build responsive, performant user interfaces using React and TypeScript
Design, implement, and maintain RESTful APIs using Java, Python, and Node.js
Create and maintain API documentation using Swagger/OpenAPI
Develop and operate containerized services using Docker and deploy on Kubernetes (EKS)
Configure, maintain, and optimize CI/CD pipelines (Drone CI, Jenkins, Spinnaker)
Monitor system health, performance, and reliability using logging, metrics, and observability tools
Debug production issues and lead root cause analysis across distributed systems
Integrate and support third-party systems, including payment platforms (e.g., Stripe)
Collaborate cross-functionally with Product, Design, and DevOps to deliver end-to-end solutions
Enforce best practices for Git workflows, code reviews, and release management
Define and uphold microservices principles, including service boundaries, scalability, and system integrations

Qualification

Microservices architectureJavaPythonNode.jsReactTypeScriptAWSDockerKubernetesCI/CD pipelinesAPI designSystems thinkingCommunication skillsTechnical leadership

Required

Design, develop, and maintain frontend and backend systems across multiple repositories
Apply systems thinking to reason about end-to-end architecture, dependencies, failure modes, scalability, and long-term maintainability
Build responsive, performant user interfaces using React and TypeScript
Design, implement, and maintain RESTful APIs using Java, Python, and Node.js
Create and maintain API documentation using Swagger/OpenAPI
Develop and operate containerized services using Docker and deploy on Kubernetes (EKS)
Configure, maintain, and optimize CI/CD pipelines (Drone CI, Jenkins, Spinnaker)
Monitor system health, performance, and reliability using logging, metrics, and observability tools
Debug production issues and lead root cause analysis across distributed systems
Integrate and support third-party systems, including payment platforms (e.g., Stripe)
Collaborate cross-functionally with Product, Design, and DevOps to deliver end-to-end solutions
Enforce best practices for Git workflows, code reviews, and release management
Define and uphold microservices principles, including service boundaries, scalability, and system integrations

Preferred

8+ years of professional software engineering experience with demonstrated impact on complex, distributed systems
Strong full-stack experience across modern frontend and backend technologies
Proficiency in systems thinking, including modeling system behavior, understanding trade-offs, and anticipating downstream effects of architectural decisions
Deep understanding of distributed systems, microservices patterns, and API design
Hands-on experience with AWS, including S3, EKS, WAF, Cost Explorer, and Bedrock
Experience integrating with Salesforce (SFDC) or PROS APIs is preferred
Strong communication skills with the ability to influence and collaborate across teams
Proven ability to balance hands-on development with architectural ownership and technical leadership

Benefits

Bonus
Equity
Generous benefits package

Company

Twist Bioscience

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Twist Bioscience is a biotechnology company that offers synthetic DNA solutions, gene synthesis, and variant libraries.
dateFounded in 2013
location
San Francisco, California, USA
people-size501-1000 employees
web-link
http://www.twistbioscience.com

H1B Sponsorship

Twist Bioscience has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (18)
2024 (14)
2023 (22)
2022 (19)
2021 (4)
2020 (6)

Funding

Current Stage
Public Company
Total Funding
$553.11M
Key Investors
Capital World InvestorsBiomatics Capital PartnersIllumina
2022-02-09Post Ipo Equity· $250M
2020-01-27Post Ipo Equity· $50M
2018-10-30IPO

Leadership Team

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Emily Leproust
CEO
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Siyuan Chen
Chief Technology Officer
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Recent News

Genetic Engineering News
Automated Twist Bioscience NGS Library Prep Workflows Enabled on SPT’s Firefly
2026-01-17
GenomeWeb
Ultima Genomics Doubled Installed Base in 2025, Entered New Year With Contracted Revenue Backlog
2026-01-16
GenomeWeb
SPT Labtech, Twist Bioscience Partner to Automate Sequencing Library Prep
2026-01-16
Company data provided by crunchbase