Stony Brook University · 4 days ago
Postdoctoral Associate
Stony Brook, NY
Full-time
Onsite
Entry Level
$50K/yr - $65K/yr
2+ years expStony Brook University is seeking a Postdoctoral Associate in the Department of Microbiology and Immunology. The role involves performing research on Powassan virus using various experimental approaches and analyzing neuropathogenic mechanisms in a murine model.
Higher Education
Responsibilities
Perform POWV experiments and data analysis following in primary cells and cell lines in BSL2/BSL3, and following murine infection in ABSL3 settings
Analyze viral responses of infected and uninfected CNS cells and assess and quantitate viral and cellular proteins and RNA transcriptional responses using immunohistochemistry, Western blot, scRNAseq, qRT-PCR and ISH
Evaluate POWV entry into the CNS and neurovirulence in a murine model and use single cell RNAseq to assess age dependent determinants of pathogenesis and immune neuropathology
Conduct experiments using recombinant approaches to generate and evaluate reverse genetics modified recombinant POWVs, develop potential recombinant POWV vaccines, and to define POWV cell protein interactions, cytokine induction, and the regulation of CNS protective immune responses
Document data generated in studies, collect data, analyze data and prepare manuscripts and figures for publication in scientific journals and national and international scientific meetings and assist with grant reports, grant proposal writing and compliance reports
General Lab maintenance and ordering of supplies needed for studies
Other duties as assigned
Qualification
Required
Doctoral Degree in Microbiology, Virology or a closely related field in hand by the time of hire
Experience with performing and evaluating viral infections and cellular responses to viral infection
Evidence of Experimental procedures used to study viral replication, spread and the induction of innate and adaptive immune responses
Use of molecular approaches to study viruses, single cell analysis and analysis of immune responses contributing to neurovirulence
Preferred
PhD or Postdoc experience in Flavivirus research
Experience in BSL3 with neuropathogenic viruses and ABSL3 murine models
Two (2)- Five (5) years of molecular biology experience with viral infected cells/mice and the use of viral reverse genetics approaches
Analysis of murine CNS and immune responses using single cell RNA sequencing, qRT-PCR analysis of cellular and viral transcripts, in situ hybridization, and flow cytometry
Experience with tissue and CNS dissociation and cell isolation
Company
Stony Brook University
The State University of New York at Stony Brook is New York’s flagship university and No. 1 public university.
10001+ employees
H1B Sponsorship
Stony Brook University has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (61)
2024 (39)
2023 (44)
2022 (31)
2021 (45)
2020 (47)
Funding
Current Stage
Late StageLeadership Team
Harold Paz, M.D., M.S.
EVP Health Sciences, Stony Brook University & Chief Executive Officer, Stony Brook Univ. Medicine
Jonas Almeida
Professor of Biomedical Informatics, Chief Technology Officer
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