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CHEManager International · 1 day ago

Research Associate/Sr Research Associate: In vivo Preclinical Research

Morgan Hill, CA

Contract

Onsite

Entry, Mid, Senior Level

2+ years exp

Aragen Bioscience is a leading contract research organization focused on accelerating product development. The Research Associate/Sr Research Associate will conduct in vivo experiments to evaluate the efficacy of client test compounds across various rodent models and support in vitro lab work.

Responsibilities

Assist in the design and execution of in vivo rodent studies across various therapeutic areas with duties including animal weighing, dose administration (e.g. subQ, IP, PO, IM, retro-orbital, IV), blood and tissue collection, necropsy, oncology and functional readouts

Perform in vivo imaging and analysis of data in cancer models

Proficient with cell culture techniques using various immortalized cell lines to support oncology studies is desired

General understanding of pharmacokinetics, pharmacodynamics, and drug metabolism

Ability to follow strict instructions on formulation of test compounds for in vivo dosing

Analyze in vivo data independently or under minimal guidance of senior scientists

Contribute to generation of reports for in vivo experiments or other related study presentations with guidance of senior scientists

Work collaboratively with cross-functional teams to support department's goals and timelines

Aid in lab equipment maintenance and general lab support

Maintain a safe laboratory environment by following standard operating procedures (SOP) and established IACUC protocols

Other related duties as assigned

Qualification

Vivo animal studiesVitro laboratory techniquesCell culture techniquesData analysis techniquesPharmacokineticsOncology modelsAssay developmentCommunication skillsOrganizational skillsAttention to detail

Required

BA/BS or MS in Biology, Immunology, Biomedical Sciences, Microbiology, Virology, Pharmaceutical Sciences, Pharmacology or a related discipline

Two or more years of laboratory experience utilizing techniques or methods required by the position or an equivalent combination of education and experience in an academic lab environment

Recent post graduates with a desire to expand their skill set are encouraged to apply

Must be comfortable working with rodents and animal derived tissues or fluids

Adept at using automated instrumentation for analysis (e.g. IDEXX or HESKA machines)

Openness to learning new methods and skills for shifting research needs based on clients

General understanding of data analysis techniques and use of software (e.g. Microsoft Excel and Graph Pad Prism)

Excellent organizational skills with attention to detail and ability to prioritize tasks to meet deadlines

Strong written/verbal communication skills for assisting with writing reports, presentations, and client interactions

Some evening and weekend/holiday hours are required

Extensive and relevant research experience using rodent models of human disease

Proficiency in a specialized therapeutic area such as fibrosis, virology, autoimmune disorders, immunology, and oncology

Experience with oncology models

Experience with in vitro / ex vivo assay development

Hands-on knowledge of general laboratory techniques, including basic molecular or cellular biology techniques (e.g. RNA/DNA isolation, gel electrophoresis, PCR, RNASeq, bacterial culture and transformation, Western Blot, ELISA, mammalian cell culture, etc.)

Working familiarity with cell based immunology techniques such as MSD/ELISA and FACS

Understanding of preclinical drug development and regulatory process

Prior experience handling small molecules/biologics for PK/PD studies