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Ayutara · 1 day ago

Research And Development Specialist

Knoxville, TN

Contract

Onsite

Mid Level

Ayutara Inc. is a radiopharmaceutical biotechnology company based in Frisco, Texas, focusing on next-generation targeted alpha therapies and precision diagnostic agents. The R&D Specialist will be responsible for conducting and managing laboratory research, analyzing data, and contributing to the development of innovative therapeutics while ensuring compliance with industry standards.

Biotechnology

Responsibilities

Design and execute preclinical pharmacology studies for radiopharmaceutical candidates

Conduct in vitro cellular assays, including cell binding and uptake, MTT viability assays, clonogenic survival, and receptor saturation/competition assays

Evaluate radiation-induced biological effects, including DNA damage, apoptosis, and cell cycle alterations

Prepare and manage in vivo tumor models and perform radiopharmaceutical therapy experiments

Perform radiolabeling of small molecules and peptides (Cu-64, Lu-177, Ac-225 preferred)

Conduct and interpret in vivo imaging studies using PET/CT and SPECT

Perform ex vivo biodistribution (BioD) analyses, including tumor uptake, organ clearance, and time-activity curves

Support dosimetry calculations using biodistribution and imaging data (OLINDA/EXM or equivalent)

Conduct histological and tissue-based analyses, including H&E staining and immunohistochemistry (IHC)

Coordinate PK/PD and target engagement studies in relevant tumor models

Analyze experimental, imaging, and biodistribution data; maintain detailed records; and contribute to study reports, manuscripts, and regulatory documentation

Collaborate with CROs, academic partners, and internal teams on GLP and non-GLP studies

Support FDA IND submissions, including Nonclinical Module 4 and Investigator’s Brochure content

Ensure compliance with radiation safety, animal welfare, and institutional regulations

Qualification

Radiopharmaceutical preclinical studiesBiodistributionDosimetryPreclinical imaging (PET/SPECT)Cell culture techniquesIn-vitro assaysIND-enabling requirementsBiotechnologyNuclear MedicineRadiochemistryTranslational research experience