TakedaPharmaceutical Nordics AB · 1 week ago
Research Scientist
Boston, MA
Full-time
Hybrid
Mid Level
$119K/yr - $192K/yr
3+ years expTakeda Development Center Americas, Inc. is seeking a Research Scientist to contribute to discovery projects in oncology immunotherapy research. The role involves designing and developing mechanistic experiments, collaborating with internal teams and external partners, and advancing novel cancer treatment products.
Pharmaceuticals
Responsibilities
Contribute to discovery projects by independently designing and developing well-defined mechanistic experiments and projects within oncology immunotherapy research focusing on leveraging Vd1 T-cells as cancer treatment
Lead from the lab to advance novel and differentiated products toward clinical milestones, by working collaboratively with internal cross-functional teams and external partners
Design, execute, and interpret functional in vitro, and ex vivo assays to understand the therapeutic mechanism-of-action and play an active role in subsequent scientific discussions to drive decisions around Vd1 T-cells as possible cancer therapy
Propose novel projects based on internal results, external partners, and published reports and demonstrate leadership through effective communication of study plans/value, and research results
Actively participate with the team to help isolate VD1 cells from blood
Tutor less experienced operators in complex procedures such as large scale Vd1 isolation from blood
Use immune cell characterization and function assessments, such as multi-color flow immunophenotyping, multiplex cytokine measurement, cytotoxicity assay, and other molecular based assays and cell-based functionality assays
Contribute to evaluation of novel engagers for Vd1 T-cells in in vitro and ex vivo model systems
Contribute to development of new assays and strategies to determine Vd1 T-cells functionality and biology to improve the efficiency of tumor control of Vd1 T-cells in presence of Cell Engagers
Collaborate with other departments to meet deadlines and generate data crucial for the programs in execution
Contribute to the writing of relevant research reports to be included in regulatory filings
Prepare and present comprehensive technical or project reports and formal presentations and posters to full range of internal/external audiences
Maintain laboratory notebooks and keep in compliance with Takeda policies; up to 20% remote work allowed
Qualification
Required
PhD degree in Biology, Cancer Studies, or related field plus 3 years related experience
Prior experience must include: Isolate, culture and expand Vd1 gamma delta T cells
Design and execute in vitro/ex vivo assays of Vd1 cell function, including cytotoxicity, survival, and proliferation
Analyze experimental data and determine the relevance of results based on background knowledge of Vd1 gamma delta cell biology
Contribute to evaluation of novel immunotherapy products based on Vd1 gamma delta cell biology
Experience with gene engineering of Vd1 cells
Benefits
Competitive compensation and benefits.
Company
TakedaPharmaceutical Nordics AB
Takeda Pharma AB is engaged in sales marketing For USA
11-50 employees
Funding
Current Stage
Early StageCompany data provided by crunchbase