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Inside Higher Ed · 9 hours ago

Postdoctoral Research Associate Dr. Counago Lab

Chapel Hill, NC

Full-time

Onsite

Senior Level

The University of North Carolina at Chapel Hill is a global leader in higher education, known for its commitment to research excellence. They are seeking a Postdoctoral Research Associate to contribute to the NIH-funded TREAT-AD Center, focusing on the discovery of therapeutic targets for Alzheimer’s disease through the development of comprehensive research tools and data.

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Responsibilities

Design and execute recombinant protein production workflows in both prokaryotic and eukaryotic expression systems

Develop and perform assays to identify and characterize protein-ligand interactions, including binding affinity, selectivity, and mechanism-of-action studies

Determine protein structures using X-ray crystallography and cryo-electron microscopy (cryo-EM) to support target validation and ligand discovery

Maintain accurate and detailed records of experimental procedures, results, and analyses

Communicate findings regularly with the project team and contribute to collaborative research efforts within the TREAT-AD network

Qualification

Molecular BiologyProtein PurificationBiochemical AssaysStructural BiologyBiophysical AssaysDNA-encoded Library ScreeningData ManagementCollaboration

Required

PhD in Biological Sciences or Chemical Biology or related field

Demonstrated proficiency in molecular biology, including high-throughput cloning and recombinant protein production using both bacterial and eukaryotic expression systems, such as baculovirus-infected insect cells

Must be skilled in the use of protein purification equipment, including high-speed centrifuges and fast protein liquid chromatography (FPLC) systems

Expertise in developing and executing biochemical assays is essential, with hands-on experience in techniques such as fluorescence polarization, time-resolved FRET (TR-FRET), FRET, and BRET

Proficiency in biophysical assay platforms, including isothermal titration calorimetry (ITC) and surface plasmon resonance (SPR), is also required for characterizing protein-ligand interactions

Contribute to the design, execution, and analysis of DEL-based ligand discovery campaigns, supporting the identification of novel chemical matter for challenging protein targets