SystImmune · 15 hours ago
Principal Scientist, Immuno-Oncology
Redmond, WA
Full-time
Onsite
Senior Level, Lead/Staff
$130K/yr - $160K/yr
5+ years expSystImmune is a leading and well-funded clinical-stage biopharmaceutical company specializing in developing innovative cancer treatments. They are seeking a highly energetic and motivated Principal Scientist with experience in discovery and development of protein therapeutics, particularly in immuno-oncology and tumor biology.
BiopharmaBiotechnologyProfessional Services
Responsibilities
Design, establish, and execute mechanism-driven in vitro and in vivo preclinical models (including ex vivo / human translational systems as appropriate) to identify and characterize novel immuno-oncology antibody therapeutics
Develop fit-for-purpose functional assays aligned to proposed MOA (e.g., immune cell activation, cytotoxicity, cytokine profiles, phenotyping) and define appropriate controls, acceptance criteria, and decision-making metrics
Drive target and pathway evaluation and translate immunobiology into therapeutic hypotheses; propose and assess bispecific, multi-specific, and combination strategies with clear differentiation and risk-mitigation plans
Serve as a scientific leader on cross-functional teams (Protein Engineering, Antibody Discovery, Analytical) to align on molecule design requirements, assay plans, and program milestones
Mentor and guide junior scientists; set technical direction, ensure high-quality execution, and champion rigorous experimental design, documentation, and reproducibility
Author high-quality study reports, protocols, and presentations; communicate program strategy and data to internal governance and external partners as needed
Contribute to IND-enabling documentation by providing clear scientific rationale, study summaries, and data interpretation for regulatory submissions (domestic and international)
Lead immuno-oncology preclinical project(s), including timelines, resourcing, and risk/issue management; drive decisions that enable progression to development
Other duties as assigned
Qualification
Required
PhD in Immunology, Cancer Biology, or related field with 5-10+ years relevant academic and/or biotech/pharma experience
Strong background in immune cell biology, T cell functional assay development, antibody-based drugs, and receptor signaling
Demonstrated expertise in immuno-oncology preclinical models and mechanism-driven in vitro assays using primary human immune cells (e.g., functional co-cultures, flow cytometry phenotyping, cytokine profiling)
Proven ability to lead cross-functional teams, mentor others, and communicate clear, data-driven recommendations
Strong organizational skills and a collaborative, agile 'can-do' mindset
Preferred
Experience advancing antibody-based therapeutics, with bispecific/multispecific and/or combination program experience preferred
Benefits
100% paid employee premiums for medical/dental/vision
STD
LTD
401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years
15 PTO days per year
Sick leave
11 paid holidays
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Company
SystImmune
SystImmune is a biotechnology company.
51-200 employees
H1B Sponsorship
SystImmune has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (14)
2023 (1)
2022 (2)
2021 (2)
2020 (1)
Funding
Current Stage
Growth StageLeadership Team
Martin S. Olivo, MD, MSc,
Chief Medical Officer
Recent News
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